Authors : Yashwitha Badam, Vijaya Mohan Rao Avisa, A Sumalatha, G Pavan Kumar Reddy, A Bhavana
DOI : 10.18231/j.ijced.2022.012
Volume : 8
Issue : 1
Year : 2022
Page No : 55-56
Dyskeratosis congenita was first described in 1960 as Zinsser-Engman-Cole syndrome. It is a rare inherited condition with a progressive nature and a tendency to involve multiple systems like pulmonary, gastrointestinal, genitourinary, cerebral, and dental. It has an X-linked recessive (most common) or Autosomal dominant or recessive inheritance with a high male preponderance. The genetic defect lies in the DKC1 gene which encodes for Dyskerin protein. Dyskeratosis congenita patients are at a higher risk of development of malignancies, pulmonary fibrosis and eventually aplastic anemia and bone marrow failure which may be the cause of death. This report details a case of Dyskeratosis congenita affecting a 21 year old male patient with the most benign presentation.
Keywords: Dyskeratosis congenital, Reticular skin pigmentation, Dystrophic nails, Oral leukoplakia, Dyskerin protein, Bone marrow failure