Authors : Anusha Babu Rajendran
DOI : 10.18231/j.achr.2020.002
Volume : 5
Issue : 1
Year : 2020
Page No : 3-8
Introduction: Leiomyomas are benign tumors arising from the smooth muscle. The uterus is the most
common site for the leiomyomas. The leiomyomas are steroid dependant tumors. Classically, believed to
be estrogen dependant tumors are now being viewed as progesterone dependant also. Uterine leiomyomas
are the most common cause for hysterectomies in the reproductive age group. Hence a knowledge of the
harmone dependancy of these tumors can be used in the treatment of leiomyomas
Aim: To study the estrogen receptor(ER) and progesterone receptor (PR) status in leiomyomas of uterus.
Materials and Methods: A retrospective study of 331 hysterectomy specimens, done for leiomyomas,
during the period June 2013-May 2015 was carried out of which 102 cases were chosen to study the ER,
PR status in the leiomyomas by Immunohistochemical (IHC) staining.
Results: It was observed that out of 102 cases 61.76% were positive for estrogen receptor and 87.30%
positivity was seen for PR.
Conclusion: Leiomyoma (22.62%) was the commonest condition noted in hysterectomy specimens. The
hormone receptor status of the leiomyoma shows that they are more progesterone dependant than estrogen
dependant substantiating the fact that the growth of leiomyoma is dependent on the progesterone.
Keywords: Er, Pr, Leiomyoma.