Kalpesh Patel

Abstract

Introduction: The present study was undertaken to evaluate the CD4 count responses in subjects who are on long term first line antiretroviral treatment (ART). Materials and Methods: A total of 200 People Living with HIV/AIDS (PLHIV), on first line ART for five years seen in the ART centre were included in the study. Patients were interviewed and details entered as per the proforma. Proforma included various details such as serial CD4 counts and Opportunistic infection pre and post ART. Results: Mean CD4 count pre ART was 171.32 ± 65.23 per mm and one year after ART was 374.56 ± 159.12. There was significant rise in CD4 count one year after the initiation of ART (p = 0.000) The mean CD4 count at the time of collection of data was 545.23 ± 259.11 as compared to mean CD4 count pre ART of 171.32 ± 65.23 per mm. The rise was significant. (National AIDS Control. OrganizationNACO) suggested first line regimens outcome in vigorous immunologic response that is continued over a mean period of over six years in a majority (84%) of the subjects and consequence in significant decline in opportunistic infections.   Keywords: ART, CD4 count, Opportunistic infection, Immunology

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Abstract

Aim: The study was done with the aim to determine the relationship between the severity of asthma in patient and the level of serum immunoglobulin E, peripheral eosinophil count and nature of sputum. Materials and Methods: Current research was conducted at the Department of Respiratory Medicine, GAIMS, Bhuj, India over one year. All subjects of Bronchial asthma distinct by Genetic Information Nondiscrimination Act (GINA) guidelines of age 17-61 year were registered. Severity of asthma was assessed by clinical features and by Forced expiratory volume in the first second (FEV1 in spirometry. Following evaluating the sternness of bronchial asthma all subjects undergo sputum examination for sputum eosinophil counts, blood sampling for absolute eosinophil counts and serum IgE levels. Results: Elevated sputum eosinophil count (>3) was significantly elevated in additional subjects with severe persistent asthma even though extra than half of them had normal sputum eosinophil. An important association amid peripheral eosinophil count, sputum eosinophil count, and serum IgE with severe persistent asthma. Mean sputum eosinophil% augments considerably according to severity, demonstrates though affirmative association which was statistically important. Conclusions: The use of inexpensive and easy method with evaluation of AEC, sputum eosinophil count and evaluation of serum IgE level showed a straight measurement of inflammation of airway and allergic etiology of illness.   Keywords: Allergic, Asthma, Absolute eosinophil count, Sputum eosinophil count

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