Authors: Meetesh Agrawal, Krishnendra Varma, Ujjwal Kumar, Shashank Bhargava, Aishwarya Mahadik, Vishal Agrawal*
Background: Melasma is one of the most common causes of hyperpigmentation and is a prevalent cosmetic concern for patients. Tranexemic acid is an effective mode of treatment available in both oral and topical forms. Aim: To evaluate and compare the therapeutic effectiveness of topical and oral tranexamic acid for the treatment of melasma. Materials and Methods: A total of 84 patients who presented to dermatology OPD with melasma were divided into two groups, namely A and B. Group A patients were treated with oral tranexamic acid 250 mg twice daily, and patients in Group B were treated with topical 5% tranexamic acid with follow-up every 4 weeks until 3 months. Results: Among the oral treatment and topical patient groups, a statistically significant difference in the mean percentage of reduction in MASI score from baseline was observed at 12 weeks (61.31±9.48 for oral vs 52.64±8.03 for topical) with p Conclusion: Oral tranexamic acid gave a more promising result when compared to topical tranexamic acid. Despite having GI disturbances with oral tranexamic acid, it had more patient compliance and could be a promising therapeutic approach for melasma. Keywords: Melasma, Oral tranexamic acid, Topical tranexamic acid, Tranexemic acid, TA
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