Bhupendra Gopalbhai Prajapati

Abstract

Exemestane HCl (EXM) is a new irreversible steroidal aromatase inhibitor for adjuvant therapy of hormonally sensitive breast cancer in post-menopausal women. EXM's low water solubility hinders solid oral dosage form development. The current work aims to increase EXM solubility by formulating the self nanoemulsifying drug delivery (SNEDDs) system. The water titration approach was employed in the development of SNEDDs. Based on solubility tests, SNEDDs components Caprol Microexpress and Labrafac were selected as oil phase, Tween 80 as surfactant, and Triacetin as co-surfactant. Phase investigations were carried out with various surfactant:co-surfactant ratios (1:1, 1:2, 1:3, 2:1, 3:1). Tween 80: triacetin (1:2) and (1:3) with Caprol Microexpress and Labrafac alone had the greatest nanoemulsion area. Visual evaluation, optical clarity, particle size, medication concentration, and viscosity were used to optimise 10 formulations. F3, F7, and F8 batches had the lowest size at 7.313 ± 1.44 nm, 6.379 ± 0.45 nm, and 14.67 ± 0.37 nm, respectively, with self-emulsification times under 1 min.But optical clarity data was suggested that F7 was not showing any precipitation up to 24 H. Overall, the developed SNEDDS formulation could be a promising approach for the improved oral delivery of EXE with enhanced dissolution and bioavailability.   Keywords: Exemestane Hydrochloride, SNEDDS, Nanoemulsion, Self emulsification

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Abstract

With time, dosage forms have progressed, from essential tablets to advanced systems, which are now more focused on providing better ease of administration to the patients. One such advantageous novel drug delivery system is Nanoemulsion based drug delivery. The Nanoemulsion-based system is reasonably a new means of enhancing drug delivery; Nanoemulsions are sub-micron size particles roughly in the size range of 50-600 nm. The review focuses on conveying information by combining various articles and study reports to understand the work done in this field. This review paper aims to serve as a tool to understand the development of Nanoemulsion. The study comprehensively analyses the preparation methods, composition, characterization, and stability and their application in drug delivery via various routes. Lastly, the paper also describes the recent five formulations prepared for nanoemulsions and their applicability as discussed in the literature.   Keywords: Nanoemulsion, Characterization Techniques, Applications

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