Chiragkumar B Menapara

Abstract

Aims & Objectives: 1. To evaluate various causes of postmenopausal bleeding in terms of functional and organic endometrial lesions on histopathological basis, 2. To confirm or to rule out the diagnosis of atypical or malignant endometrial lesions. 3. To help the gynecologists in diagnosis of endometrial cancer as early as possible. Materials and Methods: The study was carried out in the Department of Pathology, GMERS Medical College-Junagadh from January 2015 to September 2018 and includes 200 cases of postmenopausal women who presented with bleeding problems at our institute. Histopathological evaluation of endometrium was done in all these cases after clinical evaluation and final diagnosis was given in terms of organic or functional lesions. Results: Out of 200 cases, 36 cases (18%) showed organic lesions & 164 cases (82%) showed functional lesions. Among organic lesions, Simple & Typical Hyperplasia was the commonest one (12 cases), while among functional lesions, Atrophic Endometrium was the commonest one (88 cases). Atypical and Malignant lesions were commonly seen after 60 years of age. Conclusion: The role of histopathology remains always important in the evaluation of postmenopausal bleeding. Careful histopathological evaluation of endometrium is always necessary in order to confirm or to rule out premalignant or malignant lesions in order to save the patient’s life. Keywords: Postmenopausal Bleeding, Organic Lesions, Functional Lesions.

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Abstract

Introduction: For Microscopic Grading of Infiltrating Ductal Carcinoma of Breast, various scoring systems are available in Cytology. In our present study, we have selected Robinson’s scoring or grading system for comparison with Modified Bloom-Richardson’s histological grading system in terms of concordance rate between both. Material and Methods: The present study is done at the Department of Pathology, GMERS Medical College-Junagadh (Gujarat, India) from January 2015 to June 2018 and includes 50 diagnosed cases of Infiltrating Ductal Carcinoma of Breast.   Diagnosis is based upon both cytological & histological evaluation and includes microscopic grading, done by Robinson’s System in Cytology and Elston & Ellis modification of Bloom-Richardson System in Histology. Result: Out of 50 cases, 8, 24 and 18 cases are of grade I, II and III tumor respectively on cytological evaluation and 6, 25 and 19 cases are of grade I, II and III tumor respectively on histological evaluation. The concordance rates between both systems for grade I, II and III tumor are 50.00%, 83.33% and 94.44% respectively with Absolute concordance rate of 82.00%. Conclusion: Robinson’s system is easy, effective & comparable with Modified Bloom-Richardson’s system. Both are helpful in Microscopic Grading of infiltrating ductal carcinoma of breast as an indicator of tumor behavior or aggressiveness. Keywords: Cytological Grade, Histological Grade, Concordance Rate.

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