Anushree CN

Abstract

Introduction: Salivary gland lesions are morphologically and clinically diverse group of lesions which is difficult task for histomorphological interpretation. Since salivary gland tumours are uncommon owing to limited experience with them. The salivary gland system comprises three pairs of major glands (parotid, submandibular and sublingual) and about 500-1000 lobules of minor glands dispersed in the submucosa of the oral cavity. Neoplastic and non-neoplastic lesions arises from major and minor salivary glands. Materials and Methods: Present study was done for 3 years from June 2015 to June 2018. The study was done on 50 specimens from patients with salivary gland lesions which are referred to the department of pathology, DR. B R Ambedkar medical college, Bangalore, Karnataka. The gross examination was done after fixing specimen in 10% formalin and sections were stained with haematoxylin and eosin. Results: Out of 50 cases, 35 cases are neoplastic, and 15 cases are non-neoplastic. Among 35 neoplastic lesions, 20 cases are benign, and 15 cases are malignant. Most common benign tumour of salivary gland is pleomorphic adenoma followed by Warthin’s tumour. Most common malignant tumour of salivary gland is mucoepidermoid carcinoma followed by adenoid cystic carcinoma. Most common non-neoplastic lesion is chronic sialadenitis. Conclusion: From the present study, it is evident that histomorphological examination is the mainstay for the diagnosis and categorization of neoplastic and non-neoplastic lesions of salivary gland. Keywords: Salivary gland, Pleomorphic adenoma and Mucoepidermoid carcinoma.

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Abstract

Introduction: Breast lesions are a broad spectrum of lesions consisting of several distinct entities each with specific characteristics. Early evaluation of lesions with timely accurate diagnosis can alleviate anxiety of patients and also can be lifesaving. The most common cancer among Indian women is Breast cancer accounting to 25.8 per 100,000 women. Materials and Methods: A total of 100 cases of neoplastic and non-neoplastic lesions of breast were evaluated from June 2015 to June 2018 which were sent to department of pathology, Dr B R Ambedkar Medical College, Bangalore, Karnataka. Specimens were fixed in formalin of 10%. Appropriate areas were selected from the specimen and grossed, processed, sectioned, stained using haematoxylin and eosin and were observed under microscope. Results: out of 100 resected specimens, 19 cases were non-neoplastic, 46 were benign, and 35 cases were malignant. The most common benign breast lesion was Fibroadenoma (31%) and the most common malignant breast lesion was invasive carcinoma- No Special type (22%). Conclusion: Histopathological evaluation helps in distinguishing benign, insitu, borderline and malignant breast lesions and is the mainstay of accurate and confirmatory diagnosis. This helps in evaluating the risk of patient in developing cancer and appropriate treatment can be planned accordingly for each case. Keywords: Histopathology breast, Benign breast, Malignant breast lesions, Fibroadenoma, Invasive carcinoma.

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Abstract

Introduction: Gallstone disease is a major health problem and puts notable burden on individuals and health care system worldwide. This research was carried out to study the varied histopathological changes in the gallbladder mucosa as a result of cholelithiasis. Materials and Methods: The present research comprised 190 gallbladder specimens obtained from cholecystectomy procedures conducted at tertiary teaching hospital in Bangalore. The gross examination was done after fixing the specimens with 10% formalin. Haematoxylin and eosin was used to stain gallbladder sections from fundus, body and neck. Results: On gross examination, congestion was noticed on surface of gall bladder in 67 cases (35.26%), wall was thickened in more than half of cases 104 (54.74%). Nearly a quarter of specimens showed pathological changes in mucosa of gallbladder (23.15%). Histopathological examination observed evident epithelial hyperplasia in 80 cases (42.1%), antral metaplasia in 20 (10.5%), intestinal metaplasia in 12 (6.3%), dysplasia with carcinoma in one case (0.53%). Conclusion: Gallstones produce a wide range of histopathological changes in mucosa and calls for dedicated attention of pathologist routinely. Keywords: Cholelithiasis, Dysplasia, Hyperplasia, Metaplasia.

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