Volga Harikrishnan

Abstract

Introduction: The synovial membrane is a layer of specialized connective tissue that lines the cavities of joints, tendon sheaths and bursae; it secretes synovial fluid into the joint cavity. The joint diseases are common orthopedic problems. This can lead to widespread disability and morbidity. Synovial biopsy is a procedure where a sample of joint lining or synovial membrane is taken. The evaluation of synovial biopsy is an important part of investigative procedure in patients presenting with joint problems. This study aims to observe the spectrum of lesions affecting the synovial membrane of the joint. Materials and Methods: This is a type of case control study with retrospective analysis of synovial biopsy over a period of 10 months from the data collected from archives of Department of Pathology of our institution. Result: In this study increased incidence of chronic nonspecific synovitis was diagnosed. The synovial biopsy was most commonly taken in males and among the 41-50 age groups. Conclusion: Synovial biopsy is a very important diagnostic tool for early detection of the joint pathologies. This helps in better prognosis and patient care. Keywords: Chronic nonspecific synovitis, Histopathological findings, Suppurative arthritis, Synovial biopsy.

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Introduction: Prepuce is the skin covering the glans penis. The normal histological appearance of the prepuce shows a keratinized stratified squamous epithelium with ridged appearance and is rich in nerves, Schwann cells, Meissner's corpuscles, lymphoid cells, and capillaries. While the prepuce is more commonly perceived as a vestigial organ, several studies exist to demonstrate its importance in keeping the glans penis warm and protecting it in utero. The various lesions existing in the prepuce range from infectious to non-infectious (inflammatory, neoplastic, etc.).This study aims to observe the wide spectrum of lesions affecting the prepuce. Materials and Methods: A Retrospective cross-sectional analysis of preputial skin sent for analysis over a period of 10 months to the department of Pathology was done. Review of the histopathological findings, clinical findings, age, and clinical presentations was done Results: In this study, there is an increased incidence of chronic balanoposthitis in the study population. Preputial abnormalities were found to be more common in patients between 21 to 30 years of age. The most common clinical presentation observed in the patients is phimosis Conclusion: This study has revealed the existence of several common misconceptions about the prepucal skin and demonstrates the incidence of various prepucal lesions among the population. Keywords: Chronic balanoposthitis, Condylomata accuminatum, Phimosis, Prepuce.

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Introduction and Objective: Ovary is one of the complex organs in terms of its embryology, histology, steroidogenesis and tumor incidence. The present study highlights the correlation between the clinical and pathological features of neoplastic lesions of ovary in order to arrive at a better understanding of the disease process. The objective of study is to assess the overall incidence of various histological types of ovarian neoplasm, the pattern of occurrence of ovarian tumors in relation to age, parity and modes of presentations and to study the histopathological findings of various ovarian tumors. Materials and Methods: Biopsies received at the Department of Pathology, Sree Balaji Medical College and Hospital-Chrompet were subjected for histopathological study. Specimens were then fixed in 10% formalin for 24-48 hour, processed and embedded in paraffin blocks. Sections of 4-6 microns thickness were taken and stained with routine haematoxylin and eosin and studied. IHC was done whenever necessary. Result: Out of 92 cases of ovarian tumors 68 cases were benign, 3 were borderline and 21 were malignant. Serous cystadenoma formed the majority (38%) among benign lesions and among malignant lesions serous cystadeno carcinoma (5.4%) were common. Majority were surface epithelial tumors and constituted 64.13% (59 cases) with germ cell tumors 26% (24 cases) and sex cord stromal tumors 8.6% (8 cases). Interpretation and Conclusion: The correct histopathological diagnosis of ovarian tumor is of prime importance in view of their behavioural predictability, clinical correlation and the proper management of patient. Keywords: Ovary, Tumor, Histopathology.

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