Authors: Pratik Desai, Ami Shah
Introduction: The lacrimal gland is non-capsulated, multilobulated secretory gland situated in the lacrimal gland fossa. Lesion and tumors of lacrimal gland occupy almost 18% of all orbital tumors. Pleomorphic adenoma of lacrimal gland also known as mixed tumour of lacrimal gland it is the most common tumor as well as most common benign tumor of lacrimal gland and very critical to differentiate between adenocystic and pleomorphic adenoma of lacrimal gland because of different prognosis. Aims and Objectives: To study the prevalence of pleomorphic adenoma in to the lacrimal gland tumors and to study the histopathological pattern of pleomorphic adenoma in lacrimal gland, its distribution into the age, sex and its outcome in to different condition. Materials and Methods: A retrospective study of 38 cases of pleomorphic adenoma in lacrimal gland during period of 10 years were studied at tertiary care institute. A detailed history of patients were taken with special attention to the age, sex, macroscopic (gross examination) and microscopic features of tissue. Microscopic examination is done under standard H & E staining procedure. Microscopic examination is focused on specifically tumour cells size, shape, nucleus characteristics and cytoplasm and arrangement of cells. Result: Total 57 cases of lacrimal gland tumor were studied among them 38 cases (66.66%) of pleomorphic adenoma were diagnosed. Among 38 cases of pleomorphic adenoma 26 cases (68.4%) were in Female and 12 cases (31.6%) were in male. Among them most number of cases are seen in the age group of 21-40 years almost 18 cases (47.3%), and second common frequency in to the 41-60 years age group contain 13 cases (34.2%). When studied according to histological features, then Myxoid differentiation are seen in 33 (94%)cases, Squamous metaplasia are seen in 18 cases(47%), Chondroid differentiation are seen in 16 cases(42%), Cystic degeneration are seen in 12 cases (33%), Calcification are seen in 3 cases (8%), Cellular atypia are seen in 2 cases(6%), Osseous metaplasia is seen in 1 case (2.6%), Hy aline changes are seen S in 17 cases (45%), Predominantly cellular appearance in 21 cases (55.2%), Predominantly stromal appearance in 1 cases (2.6%), Mixed (cellular + stromal) 3 cases (7.9%). Conclusion: Pleomorphic adenoma is most common benign tumour of lacrimal gland tumour and its incidence are significantly higher into the female (68.4%) and most common presenting age group is 21-40 (47.3%) and if bar is raised to 21-60 years then almost 80% cases fall in this category so most commonly seen in middle age group. Keywords:Â Pleomorphic adenoma, Lacrimal gland, Histological features, Age.
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