Authors: Rashmi Raveendran, S Ganthimathy
Objective: The revised 4th edition of the WHO classification of tumours of the central nervous system categorizes meningiomas into three grades based on their histomorphology. However, the biological behaviour and recurrence rates for these tumours cannot be predicted using morphology alone. The aim of the study was to study the demography of Meningiomas and to correlate the grade with the Ki-67 Labelling Index (LI) and compare them to tumour recurrence. Materials and Methods: The study included 38 cases of Meningioma of various subtypes. Hematoxylin and Eosin slides were reviewed; appropriate blocks were sectioned and stained with Immunohistochemical marker, Ki-67. Slides were studied and Ki-67 labelling index was calculated. Results: The tumour was more common in the female population and in the 5th and 6th decades of life. The average Ki67 labelling index showed insignificant variation among tumours within the same grade (p= 0.15) but demonstrated considerable disparity with increasing grades (p < 0> of recurrence of a previous Papillary Meningioma, with a Ki-67 index of 25.32. Conclusion: Ki67 labelling index in meningiomas increases in proportion to increasing grade and is a good indicator of tumour recurrence. Some histologically benign tumours have been known to recur after complete excision. Hence, we suggest that immunohistochemistry for Ki-67 LI should be done for all cases of meningioma, irrespective of the type. Keywords: Meningioma, Ki 67, Tumor, Grade, CNS.
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