Sharmila M

Abstract

Oral cancer is the 6th commonest among all the malignancies, affecting more than half a million people each year, with a reported of 75000-80000 new cases annually in India. Among other Head and Neck malignancies, 95% of cases accounts for oral squamous cell carcinomas. According to the surveillance, Epidemiology and End results program stated that the relative prognosis rate of 62.2% is given with an overall period of 5 years. Oral squamous cell carcinoma is before to specific potentially malignant disorders, of which the most common ones are Oral leukoplakia and OSMF due to a well-known risk factors like consumption of tobacco, arecanut and alcohol. Other factors include age and family history of cancer, HPV infections, immunosuppression, UV light and some hereditary associated conditions etc. According to WHO prognosticate by 2020, the tobacco-related deaths may exceeds 1.5 million per year. Several epidemiological studies showed that smokers tends to prosper oral cancer 5-9 times than non-smokers. This case report describes a well-differentiated oral squamous cell carcinoma involving the left lateral border of tongue. Keywords: OSCC (Oral Squamous Cell Carcinoma), OSMF (Oral Submucous Fibrosis), EGFR (Epithelial Growth Factor Receptor), LOH (Loss of Heterozygosity), CGH (Comparative Genomic Hybridization).

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Abstract

Chronic ulcerative stomatitis (CUS) is an immune-mediated mucocutaneous disorder characterized clinically by erosions or ulcers involving mucosal surfaces and occasionally, the skin affecting 5% of the population. About 14% of cases exhibits concurrent cutaneous lichen planus and biopsy proven and distinct immunofluorescent features. Microscopically, the lesions usually described as clinical entity of Erosive lichen planus, which is the second most common form of oral lichen planus followed after reticular type. This case report reviews the clinical approach of Erosive oral lichen planus and timely treatment continued. Patient was counselled about the risk of malignant transformation and immediate biopsy was performed and histopathologically diagnosed as chronic ulcerative stomatitis (CUS), which may be a variant of lichen planus or a distant disease. Keywords: Chronic Ulcerative Stomatitis (CUS), Direct Immunofluorescent (DI), Stratified Epitheial Specific Antinuclear Antibody (SES-ANA), Hydroxychloroquine

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