Authors: Tapaswini Pradhan, Sumit Jhajharia, Kavita Aggarwal
Tobacco has multiple effects on the hypothalamic-pituitary-thyroid axis and the functioning of the thyroid gland. The adverse mechanisms of smoke exposure include alteration of thyroid hormone synthesis, binding, transport, storage and clearance, thereby resulting in changes in the circulating hormone concentrations. This study was designed to analyze the effect of smoking on thyroid profile, measuring serum TSH, total T3 and total T4 levels in active and passive smokers. The results revealed that both active and passive smokers had highly significant decreased serum total T3 and T4 levels along with substantially increased serum TSH levels in comparison to non-smokers (p < 0> status between the both case groups was less statistically significant (p < 0> nature of tobacco smoke on the activity of thyroid, irrespective of its nature and origin. Keywords: Thyroid profile, Active and passive smokers.
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