Authors: K. Alamelu Mangai, Vijaya Srinivasan, Santhi Silambanan
Introduction: Assessment of proteinuria and albuminuria are the major core elements in diagnosis and management of renal failure. Measurement of albumin: creatinine ratio has been chosen as the golden standard for the determination of kidney failure. Objective: The objective of the present study was to determine whether urine protein – creatinine ratio and estimated protein output( EPO) can be use d as significant indices to identify kidney injury at an earlier stage. To achieve this goal t he sensitivity, specificity and predictive values of urinary protein-creatinine ratio were compared with urinary albumin: creatinine ratio and EPO. Materials and Methods: Random urine samples were collected from 154 individuals aged between 25-65 years who attended the outpatient clinic at the hospital. Results: The urinary protein - creatinine ratio had a sensitivity of 87% and specificity of 78% respectively. Conclusion: The results substantiate that the urinary protein: creatinine ratio can be used as a reliable and non-expensive marker to screen individuals a t risk of chronic kidney failure and quantification by determining EPO is an accurate method to detect kidney failure at an earlier stage. Keywords: Sensitivity, Specificity, Renal failure, Urine protein, Creatinine ratio, Urine albumin, Creatinine ratio, Estimated protein output (EPO)
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