Mohan Jayabal

Abstract

Introduction: Heart rate variability is one of the diagnostic tests to assess the autonomic dysfunction in type 2 Diabetes Mellitus. Objective: To compare the heart rate variability (HRV) and classical autonomic function tests between type 2 DM and healthy volunteers. Materials and Methods: This study was conducted in 30 type 2 Diabetes mellitus patients and 30 healthy volunteers. Average age of diabetic patients was 48.535.12 (mean SD) and that of volunteers was 47.103.59 (mean SD). ECG recording was done in supine position for 5 minutes in computerized physiography. HRV analysis was done using Finland software. Classical autonomic function parameters such as deep breathing difference test, heart rate and blood pressure response to hand grip dynamometer test and valsalva ratio test were recorded in them. Results: Statistical analysis was done using student’s t-test. HRV showed statistically significant impairment between cases and controls (p very significant impairment between cases and controls (p Conclusion: HRV and Classical autonomic function tests reveals autonomic impairment in Type 2 DM, but classical autonomic function test findings showed very significant (P analysis (P Keywords: Heart rate variability, Classical autonomic function tests, Type 2 DM.

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Abstract

Introduction: Autonomic dysfunction is one of the sequels in type 2 Diabetes Mellitus and various diagnostic tests have been developed for assessing it. Analysis of classical autonomic function test is one among them. Aims and Objectives: To compare the classical autonomic function tests in good control, poor control and very poor control type 2 diabetes mellitus. Materials and Methods: This study was conducted at the PSG Institute of Medical Sciences and Research, Coimbatore, Tamil Nadu, India, on 30 patients with type 2 diabetes mellitus.HbA1c investigations was done for all 30 patients. Average age of the Diabetic patients was 48.53 ± 5.12 (Mean ± SD). After obtaining informed, written consent, cardiorespiratory parameters such as resting heart rate (HR), systolic blood pressure, and diastolic blood pressure were measured after 10 min of supine rest. Autonomic function parameters such as HR and blood pressure response to handgrip, deep breathing difference test, and Valsalva ratio were recorded in them. Results: Statistical analysis was done using students’s t-test, which showed statistically non-significant impairment between good control and poor control and very poor control subjects. Conclusion: Results of this study showed autonomic impairment was present in all 3 groups of Type 2 diabetes and statistically not significant differences in impairment were noticed between the groups. This showed autonomic impairment starts and persists from the onset of type 2 diabetes. Keywords: Type 2 diabetes, HbA1c, Classical autonomic function tests.

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