Gita Chawla

Abstract

Di-Schiff’s bases are normally synthesized from aldehyde and diamine using organic solvents under conditions that remove water azeotropically. Here is a report for the preparation of di-Schiff’s base using both the conventional method and pure water without a catalyst and results were compared. It was observed that yields are better and reaction time is comparatively less when water is used as a solvent. Keywords: Benzene, Water, Green chemistry.

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Abstract

HPLC is an analytical technique widely used for identification, separation, detection and quantification of various drugs and its related degradants. Appropriate mobile phase, stationary phase, column, column size, temperature, wavelength and gradient selection is important for the suitable compatibility and stability of drug as well as impurities and degradants. Most of the drugs as well as other compounds can be analyzed by HPLC method because of the several advantages like rapidity, specificity, accuracy, precision and ease of automation in this method. This article has been prepared with an aim to review different aspects of HPLC, such as principle, types, mode of separation, characteristics, instrumentation, important parameters and various applications of HPLC in different fields. Keyword: HPLC, Analysis, Method development and Validation, Detection, Identification, Quantitation.

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