Sankappa P. Sinhasan

Abstract

Male Breast Carcinoma (MBC) is a rare condition accounting for risk factor includes hormonal imbalance, Klinefelter syndrome, testicular disorders, radiation exposure, alcoholism and antiandrogenic medication. MBC clinically manifests as painless palpable mass sometimes masquerading gynecomastia. Compared with female breast cancer, male breast carcinoma presents slightly older age at diagnosis with large tumor size and most of the tumors hormone receptor positive. We come across chronic alcoholic male presented with fungating growth over left breast. Cytology revealed neuroendocrine type of infiltrating ductal carcinoma cells, whereas biopsy showed various histological patterns in sections from different areas making this case interesting one. Immunohistochemically, it was positive for estrogen and progesterone receptor but negative for Her2neu marker. Keywords: Male Breast Carcinoma, Comedocarcinoma, Neuroendocrine, Cribriform, Schirrous, Mucinous.

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Abstract

Rheumatic heart disease (RHD) still remains one of the leading causes of death in children and young adults. It is a major public health problem owing to the issues of overcrowding, poor hygiene and low adherence to secondary prophylaxis. We present a case report of adolescent orphanage girl died in suspicious manner and found to have RHD on histopathological study of her heart. This case highlights importance of early diagnosis of the disease that would have possibly avoided preventable cause of death in teenage girl. The interesting findings we noticed in this case report is presence of myxoid area of left ventricle which showed extensive collection of Anitschkow cells and chronic inflammatory cells, and we didn’t get reference of similar findings in the literature search of rheumatic heart disease. The heart with pericardium together weighted 620 gm which is maximum weigh we encountered in our experience.  Keywords: RHD, Anitschkow Cells, Aschoff bodies, Autopsy.

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