Authors: Tarun Joseph, Rekha Kurian, Kurian Joseph, Sivashannkari, Vasanthi Balamurugan
A number of physiologic cutaneous changes occurs during pregnancy due to immunologic, hormonal or metabolic factors. Pathologic skin lesions are rare but its important to distinguish due to potentially detrimental effects on both mother & fetus. Pemphigoid gestationis is a rare pruritic autoimmune dermatosis associated with several adverse fetal outcomes. 30yrs old primigravida at 22weeks gestation presented to us with an intensely pruritic vesicobullous lesion which was further diagnosed as pemphigoid gestationis. Hence patient was started on Prednisone & Azathioprine, then gradually tapered to appropriate maintainance dose. Patient had preterm rupture of membranes and delivered a healthy baby vaginally. Proper management of this dermatological condition requires a suitable drug therapy, close monitoring and multi disciplinary team approach which is essential to reduce maternal and neonatal morbidity and to achieve favourable obstetric outcome. Keywords: Pemphigoid gestationis, Autoimmune dermatosis, Vesicobullous lesion, Prednisone, Azathioprine
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