Sulav Sapkota

Abstract

Aims: To study the clinico-pathological features of acute leukemia as second malignancy in primary solid cancer after conventional treatment. Objectives: To study and compare the demographics, treatment and prognosis of acute leukemia and solid cancer as second malignancy. Materials and Methods: It’s a retrospective study conducted over period of nine years in our centre using computer based data base and medical records as the data source from the department of medical oncology and hematology. Result: Total 17 patients were diagnosed with primary solid cancers who underwent conventional treatment including surgery, chemotherapy and/or radiation. Majority of cases were female patient (64.7%) with mean age of 58 years (range 39-96yrs) diagnosed as primary solid cancer with stage 3 (52.94%). With stage2 (41.17%). Out of 17 patients, only 4 patients (23.5%) developed acute leukemias which included 3 AML and 1ALL. Of these four patients, only one could be salvaged for about a year with allogenic transplantation while rest three died within a month in an average. Conclusion: Acute leukemias are one of the worst second malignancies that might occur after conventional treatment in solid cancers which should be regularly monitored during the follow up period. Keywords: Acute leukemia, Solid cancer, Treatment.

Open full article page

Abstract

Introduction: Nasal NK/T-cell lymphoma is a rare extranodal large cell lymphoma that involves the nasal cavity. In majority of cases, Epstein Barr virus is present and Immunophenotype shows CD3 and CD56 positivity. Loco-regional relapse is very common with poor prognosis. Case Report: We report a case of Relapsed NK cell Lymphoma of the orbit and scalp region in a young boy with EBV negativity, CD3 negativity and clinically aggressive disease. Despite aggressive treatment, our case relapsed early and was complicated by prolonged pancytopenia, CNS involvement and patient died less than one year following diagnosis. Conclusion: NK cell lymphoma is an aggressive cancer with high mortality. Multidisciplinary modalities are essential to treat the NK cell lymphoma with radiotherapy, chemotherapy, newer agents, and hematopoietic stem cell transplantation. Keywords: NK/T cell Lymphoma, Immunopheno type, Scalp, Orbit.

Open full article page

Abstract

Aims: To study the clinico-pathological features of solid cancer as second malignancy in primary hematological cancer after conventional treatment. Objectives: To study the demographics, treatment and prognosis of solid cancer as second malignancy. Materials and Methods: It’s a retrospective study conducted over period of nine years in our centre using computer based data base and medical records as the data source from the department of medical oncology and hematology. Result: Total 5 patients were diagnosed with primary hematological cancers who underwent conventional treatment and later developed second malignancy. Majority of cases were female patient (60%) with mean age of 49.8 years (range 27-72 yrs) diagnosed as primary hematological cancer with advanced stage. Out of 5 patients, only 4 patients (80%) developed solid cancers which included 2 breast cancers,1 cervix cancer and 1 head and neck cancer. Of these four patients, three could be salvaged with conventional treatment while one was lost to follow up. Conclusion: Solid cancers are one of the rare second malignancies that might occur after conventional treatment in hematological cancers which should be regularly monitored. Keywords: Solid cancer, Treatment, Hematological cancer.

Open full article page