Neha Verma

Abstract

Purpose: The aim of this study is to report the efficacy of topical Mitomycin-C (MMC) as adjunctive treatment following primary excision of ocular surface squamous neoplasia (OSSN). Materials and Methods: After detailed evaluation, 25 eyes in 25 patients with localized primary OSSN were selected in a prospective, interventional study and subjected to primary excision followed by the application of topical 0.04% MMC as an adjunct and thereafter followed up over a 24 month period for signs of any tumor recurrence. Result: The 25 patients selected with primary OSSN had a mean age of 64(SD 13) with a range of 47-87 years. They underwent surgical excision followed by 3 cycles of freshly prepared 0.04% MMC with 2 weeks on and 2 weeks off for 12weeks.All patients were followed up thereafter at 1 week, 2 weeks, monthly for 6 months and every 3 months for the next 24 months. No tumor recurrence was observed in any of the cases. Conclusion: Topical MMC has a definite role in preventing tumor recurrence when used as adjunctive treatment following primary surgical excision of OSSN. Keywords: MitomycinC (MMC), Ocular surface squamous neoplasia (OSSN), Tumor recurrence.

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Abstract

Purpose: To compare the effectiveness of external dacryocystorhinostomy(DCR) with Silicone tube(SI) placement versus Silicone tube with application of Mitomycin–C(MMC) in Nasolacrimal Duct Obstruction(NLDO). Materials and Methods: The study was conducted in the department of Ophthalmology, at BRD medical college, Gorakhpur, U.P., India between March 2018 to June 2019.It was a prospective randomized study, where we studied 88 eyes from patients who presented with simple epiphora due to primary acquired NLDO. The patients were randomly assigned into two groups, where one group was subjected to external DCR along with the placement of a silicone tube ,and the other group underwent silicone tube placement followed by the application of 0.2mg/ml of anti-metabolite MMC. Results: After a 6 month follow-up, it was noted that there was no statistically significant difference between the two groups, i.e., when considering patients with simple epiphora secondary to primary acquired NLDO, external DCR with silicone tube and silicone tube with MMC(0.2mg/ml) application are at par with each other in terms of effectiveness. However, silicone intubation with MMC is a minimally invasive procedure when compared to external DCR with silicone tube placement. Keywords: Nasolacrimal duct obstruction, External dacryocystorhinostomy. Mitomycin C, Silicone tube.

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