Varsha A

Abstract

Amniotic membrane transplantation is the newest approach to limbal stem cell transplantation for the reconstruction of ocular surface disorders. Amniotic membrane grafting helps in promoting epithelialisation, decreasing inflammation and suppressing fibrosis. Purpose: To evaluate the use of amniotic membrane graft in patients coming to Dr B.R. Ambedkar Medical college OPD and IPD with various ocular surface disorders. Materials and Methods: The prospective interventional study was conducted over a period of 18 months from June 2017 to November 2018 at DR. B. R. Ambedkar medical college and hospital, Bengaluru. A total of 46 eyes of 46 patients were taken into the study. Consecutive patients with ocular surface disorders including primary pterygia and chemical injury underwent amniotic membrane transplantation and were followed for 6 months. Results: In our study, 46 patients were enrolled including 26 males and 20 females with mean age of 43.3 +/- 12.97 years. Of these, there were 40 patients with Pterygium (87%), 6 patient’s had chemical burn (13%). Out of 40 cases with primary pterygium, 35 cases (87.5%) showed no recurrences at the 6th month of follow up, 5 cases (12.5%) showed superficial vascularisation and re-growth upto 2mm crossing the limbal margin. The recurrence was early in two cases (5%) and late in three cases (7.5%). Out of 6 cases with chemical injury, 4 patients (66.6%) had successful outcome. Conclusion: Amniotic membrane transplantation is a safe and effective surgical technique for ocular surface disorders. Keywords: Amniotic membrane transplantation, Ocular surface disorders.

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Abstract

Aim: To study the correlation between type 2 diabetes mellitus and central corneal thickness in patients coming to the outpatient department of Dr. B.R. Ambedkar Medical College and Hospital. Materials and Methods: This prospective case control study was conducted over a period of 1 year from June 2018 to June 2019 at DR. B. R. Ambedkar Medical College and Hospital, Bangalore. A total of 120 patients were enrolled in the study. Among them, 60 patients had type 2 diabetes mellitus and 60 patients were non diabetics. Detailed ophthalmic examination was conducted in all patients and Central corneal thickness was measured using ultrasound pachymetry. Results: In our study, 120 patients were enrolled including 60 diabetics and 60 non diabetics. The mean central corneal thickness in diabetics was 56722m and in non diabetics it was 520 23m. The difference between cases and control group was found to be clinically significant. Conclusion: According to our study, the patients with type 2 diabetes mellitus were found to have thicker corneas as compared to non diabetics. Keywords: Type 2 diabetes mellitus, Central corneal thickness, Ultrasound pachymetry.

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