Animesh Saxena

Abstract

Acne is defined as a chronic inflammatory disorder of the pilosebaceous unit, which is characterized by comedones, seborrhea, pustules, nodules, pseudocysts and scarring, in some cases. Benzoyl peroxide (BP) is a time tasted molecule in the management of acne. In current study we have tried to compare efficacy of benzoyl peroxide with hydrogen peroxide (HP) in acne vulgaris (AV). Aims: To study efficacy and local tolerability of BP and HP in Acne Vulgaris treatment. To compare the efficacy and local tolerability of BP gel and HP cream in a Acne Vulgaris (GRADE 1 AND 2) treatment.  Materials and Methods: A double blinded, randomised control study for the duration of 18 months was carried out in which a total of 150 patients of acne vulgaris (Grade 1 & 2) between the age of 13-30 years of both genders were recruited, which were divided in two groups, with one group treated with benzoyl peroxide gel 2.5% and second group being treated with hydrogen peroxide cream. All the data analysis was done using IBM SPSS ver. 20 software. Results: Both drugs were found to be equally efficacious in reducing acne lesions. Hydrogen peroxide group experienced less side-effects as compared to benzoyl peroxide group. Conclusion: Hydrogen peroxide and benzoyl peroxide are equally efficacious. Key Messages: In acne grade one and two benzoyl peroxide and hydrogen peroxide are equally efficacious though hydrogen peroxide has less adverse effect. Keywords: Acnevulgaris, Benzoyl peroxide Hydrogen peroxide.

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Abstract

Introduction: Vitiligo affects patients profoundly as onlookers tend to stare at individuals with Vitiligo which impacts social life of patients and family members. Family members are hidden patients which are often missed in clinics, they suffer psychologically and never seek consultation for their suffering. Objective: To analyze effect of vitiligo on family member’s quality of life and to identify the different aspects of a family member’s FDLQI that may be affected by having a family member with Vitiligo. Materials and Methods: Consenting adults family members of 50 patients with Vitiligo, attending the OPD of a tertiary care, teaching hospital completed the standard FDLQI questionnaire. Results: Based upon the FDLQI scoring, quality of life of 62% of patient’s family member were found to be affected in varying degrees (mean total score: 11.947.721). 10 aspects of FDLQI of family members were identified which were adversely affected the patients skin disease. These were categorized into 10 main topic areas: Emotional distress (70%), Physical well-being (56%), personal relationship (58%), People’s attitude (66%), Social life (56%), Leisure activities (52%), Burden of care (74%), Effect on housework (52%), Financial aspect (78%). Conclusion: Vitiligo can have a profound impact on not just patient’s but his/her family member’s quality of life. Keywords: Depigmentary disorder, Family dermatology life qualityIndex, Gender, Quality of life, Vitiligo.

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