Natasha Radhakrishnan

Abstract

Purpose: To study whether postnatal weight gain pattern can be a predictor of severe ROP. Materials and Methods: We conducted a prospective observational studyBirth weight and weight gain was recorded at 2 weeks,4 weeks and 6 weeks for all premature babies undergoing screening for ROP in our ROP clinic and NICU. The weight gain data was collected for those who developed any grade of ROP-these babies were followed up for spontaneous regression or given laser treatment for Type 1 ROP.Type 1 ROP which required treatment was termed as Severe ROP.The weight gain parameters analysed were absolute weight gain at 2,4 and 6 weeks and weight gain proportion Results: We included 94 babies were included in the study. Out of 94, in 73 babies spontaneous ROP regressed was noted and 21 developed severe ROP. Mean birth weight in treated babies and non-treated babies were 909.29 ± 210.88 grams and 1107 ± 375.00 grams respectively. Absolute weight at 2,4 and 6 weeks were significantly low in severe ROP. Weight gain proportion at completed 2,4,6 weeks of life showed that at 4 weeks it was significantly (p 0.025) low in severe ROP. Weight gain per week at 4 and 6 weeks was low in Type I ROP babies (P 0.006 and 0.016 respectively) Conclusion: In conclusion, this study found that postnatal weight gain is a significant factor that can predict the progression of ROP and those babies having a lower weight gain proportion in first 6 weeks should be followed up very closely for ROP progression.   Keywords: Retinopathy of prematurity, Predictive factor, weight gain

View Article

Abstract

Purpose: To identify baseline qualitatative OCT biomarkers that can predict good visual outcome in diabetic macular edema after treatment. Study design: Prospective, observational study in the time period. Materials and Methods: We included 37 eyes of 37 patients with treatment naïve diabetic macular edema who subsequently underwent treatment with injections of intravitreal Ranibizumab. Inclusion criteria was: Presenting vision < 0>250 microns). 3 injections were given monthly irrespective of treatment response followed by PRN dosing. Factors under evaluation were: 1) Submacular detachment (SMD) (2) cystoid changes in the inner and outer nuclear layer (4) Integrity of IS-OS junction. (5) Hyper Reflective Foci(HRF) and location (6) vitreomacular interface (7) Disruption of inner retinal layers(DRIL) Results: We included 37 eyes in our study. For analysis, based on final visual acuity patients were divided in two groups: (1) Group A: Good visual acuity (>10 ETDRS letter gain) and (2) Group B: Poor visual outcome (< 10> Conclusion: Presence of SMD was found to have most significance in predicting good visual acuity response to anti VEGF.DRIL was found to decrease during the treatment but a predictive role could not be demonstrated.   Keywords: Diabetic maculopathy, Diabetic macular edema, OCT biomarkers

View Article