Mohammed Jaffer Pinjar

Abstract

Diabetes Mellitus is the most common non-communicable disease which is vastly conquering both the developed & developing countries of the world. Hypothesis: serum uric acid plays as an independent risk factor for the development of type 2 diabetes. Studies revealing the clearance of uric acid reduced with insulin resistance are few in numbers. A positive correlation between uric acid and glucose levels leads to the development of type 2 diabetes. Objective: To correlate the levels of blood uric acid with the duration of diabetes in type 2 diabetics. Materials and Methods: Fifteen type 2 diabetes patients with no history of any complications and other systemic organ & metabolic disorders like gout & obesity randomly selected for this cross-sectional study. A biochemical investigation, like the Uricase method employed for fasting serum uric acid levels estimation. Statistical analysis by the Pearson correlation test used. Results: Positive correlation of serum uric acid with the duration of diabetes in type 2 diabetic patients found to be statistically significant (r = +0.6, p < 0> Conclusion: The positive association of fasting serum uric acid with the duration of type 2 diabetes suggests that uric acid acts as an independent biochemical marker for prognosis of the type 2 diabetes. Drugs that reduce the uric acid levels may be useful in avoiding the development and prognosis of insulin resistance that causes type 2 diabetes and other complications. Keywords: Insulin resistance, Uricase method.

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