Gaurav D Modi

Abstract

Introduction: Diabetes mellitus is a metabolic disorder in which metabolism of various trace elements is being altered. Present study has been carried out to determine association between serum ferritin and type 2 diabetes mellitus. Aim: To analyze level of serum ferritin in type 2 diabetes mellitus patients in comparison with healthy controls. Materials and Methods: The present cross-sectional study was carried at Clinical Chemistry Laboratory, department of Biochemistry, GMERS Medical College and Hospital, Vadnagar, Gujarat. There were 100 cases having minimum 5 years history of type 2 diabetes mellitus residing at North Gujarat. There were 100 healthy controls in this study. GOD-POD (Glucose Oxidase- Peroxidase) method was used for estimation of Glucose.Nephelometry method was used for estimation of Ferritin and HbA1c. Results: In comparison to healthy controls; Serum ferritin level was found high in Type 2 DM patients. Conclusion: High level of serum ferritin was found in patients of type 2 diabetes mellitus patients who have poor glycemic control. Keywords: Type 2 diabetes mellitus, Serum ferritin, HbA1c.

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Abstract

Introduction: As Diabetes Mellitus is a metabolic disorder, where metabolism of various trace elements is being altered. Present study has been carried out to find out the association between Diabetes Mellitus and alteration in the level of trace elements. Aim: To analyse the level of trace elements (Copper and Zinc) in type 2 DM patients in comparison with healthy controls. Materials and Methods: The present cross sectional study was carried out in 100 patients, having minimum five-year duration of Type 2 Diabetes Mellitus. The study was carried out in Clinical Chemistry Laboratory, Department of Biochemistry, GMERS Medical College and Hospital, Vadnagar, Gujarat. FBS was estimated by GOD-POD method. Serum Copper and Serum Zinc levels were assessed colorimetrically. Results: In our study, serum copper level was found high in Type 2 DM patients and serum Zinc level is decreas ed in the patients of Type 2 DM. Conclusion: Alteration in levels of Copper and Zinc are found to be important predisposing factors for patients of diabetes mellitus for developing complications. From the present study it may be concluded that alteration in levels of trace elements like Cu and Zn may have a role in the pathogenesis and progression of Diabetes Mellitus. Keywords: Trace element Copper, Zinc, Type 2 Diabetes Mellitus.

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