Authors: Kanchan Upadhye, Kirti Charde, Gauri Dixit, Suparna Bakhle
Background: Aphthous stomatitis or mouth ulcers is the most common condition that we encounter. Clinically the lesions are single or multiple superficial and deep sealed and are associated with microbial invasions. Aim: This study was conducted with the aim of evaluating the effectiveness of herbal drugs for treatment of Aphthous stomatitis. Materials and Methods: In the research work, mouth ulcer gels were formulated incorporating the ethanolic extracts of as Aloe barbedensis, Ocimum tenuiflorum and Azadirachta indica using carbopol 934 as the gelling agent. Seven batches were formulated by varying the concentration of the herbal ingredients (F1 to F7)The prepared formulations were evaluated for various parameters like physical appearance, pH, Spreadability, Homogeneity and antimicrobial activity against fungi and bacteria. The antimicrobial activity was also compared with a marketed gel formulation. Results and Discussion: All the prepared formulation using different concentration of plant extract showed the pH values in between 6.10.2 to 7.00.1. The spreadability values ranged between the 5.0 to 8.0 cm. Out of all the formulations, formulation F7 containing all the three herbal extracts showed a good spreadability and very promising antimicrobial activity comparable with a marketed gel. Conclusion: Thus stable, effective gels containing herbal ingredients for management of mouth ulcers can be developed. Keywords: Aphthous stomatitis, Aloe barbedensis, Ocimum tenuiflorum, Azadirachta indica, Carbopol 940.
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