Riddhi Jaiswal

Abstract

Warthin’s tumor is the most common monomorphic adenoma of the parotid gland. It can be coexistent with other salivary gland tumors or can be metachronous, multifocal, unilateral, bilateral which perplexes the diagnosis hence delaying or over/under treating the ailment. Rare cases of Warthin’s tumor are described in young population especially young non-smoker females. We present a case of Warthin’s tumor arising in the left parotid gland of 20-year-old female.   Keywords: Warthin tumor, Parotid glands, Benign salivary gland tumors, Papillary cystadenoma lymphomatosum

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Abstract

Aims: 1) To detect Cyclophilin, APC and SFRP5 genes associated with Epithelial ovarian cancer by PCR. 2) To study and compare the prognostic and diagnostic efficacy of serological markers like Ca 125 and HE4 and their correlation with epithelial/ non epithelial ovarian neoplasms. Settings and Design: Comparative observational study, Prospective study Methods and Materials: 64 cases fulfilling the inclusion criteria and giving their consent for inclusion in the study were enrolled as subjects of the present study over a period of one year. After DNA extraction (Invitrogen mini kit, USA) conventional PCR to amplify the extracted DNA and further subjected them to agarose gel electrophoresis for the identification(expression) of 3 genes i.e Cyclophillin, APC and SFRP5, was done; However, none expressed. Methods and Materials: ELISA was used to assess CA125 and HE4 pre and post surgical intervention. Results: The serum markers were raised more in malignant epithelial ovarian cancer cases and levels plummeted after surgical intervention, as compared to benign masses. Results: We could not establish correlation of the genes’ expression with the serum markers and histopathology. Conclusions: Combining HE4 and CA125 both might be more helpful than either of them using alone, in diagnosing as well as prognosticating ovarian diseases. Conclusions: A panel of multiple genes on a larger sample size may be needed for CTC detection. Key Messages: Early detection of ovarian tumors leads to early diagnosis and hence early institution of intervention and hence decreased morbidity and mortality.   Keywords : Ovarian lesion, Circulating tumor cells, Serum CA125, Serum HE4

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Abstract

Rhabdomyosarcoma (RMS) is a malignant mesenchymal (myogenic) tumor , and diagnosed on cytology as one of the Blue round cell tumors of paediatric age group. Here we are reporting a case of right side abdominal mass in a three-year-old child whose FNA smears, along with immunocytochemistry was diagnosed as RMS. The intriguing finding on smears was the presence of a large number of malignant elongated cells which stained with both desmin and myogenin, as crisply as the round cell component. The diagnosis of Spindle cell variant of subtype, embryonal was further confirmed on histopathology sections and extended IHC panel. This variant is itself rare and nonparatesticular regions are further infrequent in paediatric population. Keywords: Paediatric, Rhabdomyosarcoma, Spindle cell.

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