Deepak Grover

Abstract

With the advanced and improved knowledge of bone regeneration on the molecular level, some of key molecules that alter the complicated physiological method were identified, and are already in scientific use or beneath research to enhance bone restore. Of those molecules, BMPs were the maximum considerably studied, as they are robust osteoinductive elements. They result in the mitogenesis of mesenchymal stem cells (MSCs) and different osteoprogenitors, and their differentiation in the direction of osteoblasts. Other growth factors except BMPs which have been implicated through out the bone regeneration, with one-of-a-kind features with respect of cell proliferation, chemotaxis and angiogenesis, are also being investigated or are presently getting used to reinforce bone restore, which include platelet-derived growth factor, transforming growth factor- β, insulin-like growth factor-1, vascular endothelial growth factor and fibroblast growth factor, amongst others. One present day technique to enhance bone regeneration and soft-tissue recovery with the aid of using nearby application of growth factors is the use of platelet-rich plasma, an extent of the plasma fraction of autologous blood with platelet concentrations above baseline, that is wealthy in most of the aforementioned molecules. This overview focuses and target on the biological mediators that regulates key cellular events which have a capacity to induce the method of tissue repair and regeneration.   Keywords: Growth factors, PRP, BMP, Biological mediators, Regeneration, Wound healing.

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Abstract

Oral squamous cell carcinoma (OSCC) is the most common malignancy affecting the oral cavity. OSCC presents diverse clinical features including small ulcerative lesion to a large growth. The treatment modality of OSCC depends upon the severity, progress and spread of the disease. The purpose of this case report is to emphasize the etiological factors, clinical features as well as the management protocols of OSCC. Keywords: ­ OSCC, Tobacco, Metastasis.

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Abstract

The three-dimensional printing has been used since very long ago in the field of medicine as well as in dentistry. The evolution of 3-dimensional imaging and modelling in dentistry is progressing towards a more efficient and cost-effective workflow using state-of-the-art technology. The practicability of this technique is expanding in several dental fields such as prosthodontics, oral and maxillofacial surgery and prosthesis, and production of surgical guides or physical models in dental implant treatment. The key of success in this technique depends on the usage of various materials such as, metal, resin, plastic etc. which is most commonly used in dentistry. With introduction of this recent advanced technology, it is used in various surgical procedures such as ridge augmentation, sinus lift and guided implant surgery, implant fixtures, preparation of customized scaffold with or without stem cell therapy, education models as well as in drug delivery technology. The 3-dimensional printing technology is becoming more economical technique and able to produce replica of dental models with a high resolution and accuracy. Keywords : Printing, Guided bone regeneration, Scaffold, Bioprinting, Stereolithography, Tissue engineering.

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