Ajay Kumar Meena

Abstract

Background: Herbal medicines, the backbone of traditional medicine in many countries have played an important role in curing the various diseases of humans and animals since ancient time. Medicinal plants are great source of bioactive compounds that have potential beneficial effects in human life. Materials and Methods: Electronic databases including PubMed, Google Scholar, books and other sources were searched using subject specific key words that were matched by Trichosanthes tricuspidata medicinal plant related useful information on botanical description, plant distribution, ethanobotanical & therapeutic uses, chemical constituents and pharmacological activity etc. Conclusion: Trichosanthes tricuspidata have many medicinal properties like antioxidant, anticancer, antibacterial, antifungal, Larvicidal activity, Anticonvulsant activity, Gastro protective activity and other activities. The Bioactive compounds of Trichosanthes tricuspidata responsible for its various medicinal properties and their effects at the molecular level need to be investigated in more detail. The present review summarizes the Ethnobotanical & therapeutic uses, chemical constituents and pharmacological activity information of Trichosanthes tricuspidata. The pharmacological properties of bioactive compounds in Trichosanthes tricuspidata are required to confirm the ethno medicinal or traditional claims of Trichosanthes tricuspidata for pharmaceutical therapeutic applications.   Keywords: Trichosanthes tricuspidata, Pharmacological activity, Ethnobotanical, Chemical constituents, Herbal products

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Abstract

Herbal medicines mainly based on plants enjoy a respective position today, especially in the developing countries, where modern health services are limited. Popularity of herbal drugs is increasing all over the world because of lesser side effects as compared to synthetic drugs besides it cost effectiveness and easy availability to poor people particularly in developing countries. The present study aimed to estimation of four heavy metals namely Iron, Cadmium, Lead, and Mercury in Vitex negundo leaves. In study we observed the road side sample contain more heavy metals compared to two other site samples. Lead, cadmium, mercury and iron accumulation 6.05, 0.29, 0.07 & 4.75 mg/kg, was found in road side sample S3 respectively. All the sample heavy metals concentrations are below the World Health Organization (WHO) and Ayurvedic Pharmacopoeia of India (API) permissible limits. The estimation of heavy metals is highly essential for raw drugs used for the preparation of herbal products. The periodic assessment is essential for quality control/ quality assurance and safer use of herbal products. Keywords: Vitex negundo, Leaves, heavy metals, Quality control, Herbal products, Contamination.

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Abstract

Background: Ayurvedic medication pancha nimba choorna is a herbal powder. The panchanimba is a well-known medication stated in the old Ayurvedic texts used to cure kshudra kushtas (minor skin disorders), such as eczema, acne, and Maha kushtas (major skin ailments).It is used to treat a variety of skin conditions, including dermatitis, pruritis, psoriasis, sinus, non-healing wounds, headaches, uti, diabetes, toxins, and arthritis. It is employed to treat infections of the skin. The traditional use of the neem tree's leaves, blossoms, seeds, fruits, roots, and bark for the treatment of inflammation, infections, fever, skin conditions, and dental problems includes all of these parts. Neem leaf's therapeutic benefits have been specifically discussed. The immunomodulatory, anti-inflammatory, anti-hyperglycaemic, antiulcer, antimalarial, antifungal, antibacterial, antiviral, antioxidant, antimutagenic, and anticarcinogenic activities of neem leaf and its components have been proven. Protein, carbohydrates, flavonoids, phenol, saponin, glycosides, tannin, and alkaloids are all present according to phytochemical analysis, whereas terpenoids, sterols, and other substances are not present. Results:To guarantee the quality of the product, standardization employing various parameters was used which was performed as per the Indian Pharmacopoeia, WHO guidelines and various literature reports. The antioxidant activity may be attributes to flavonoids and phenolics present in extracts of . In terms of gallic acid equivalent, Panchanimb Churna contained 105 mg/g of total phenols and the total flavonoid concentration was 43.8214 mg/g, which is the quercetin equivalent.Antioxidant property was evaluated using DPPH activity. Conclusion: According to a forementioned quality criterion, Panchanimb Churna was determined to be competent under every examined aspect. The current study strengthens belief in herbal remedies of natural origin to combat infectious diseases and other illnesses that may be included in medications in the future. Overall the product is very beneficicial in day to day life for humans as it possess various qualities and activities. Keywords: Standardization, Panchanimba Churna, DPPH, Anti-Microbial, Anti-Inflammatory, Anti-Oxidant

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