U. Srinivasa Rao

Abstract

Objective: Comparative studies evaluating budesonide and saline nasal irrigations for patients with polyposis/ rhinosinusitis are deficient in the current literature. This study aimed to evaluate the effectiveness of budesonide nasal irrigations compared with saline irrigations during postoperative care of patients with rhinosinusitis. Materials and Methods: A total of 100 patients who underwent functional Endoscopic Sinus SurgeryESS) were randomly divided into two groups (A and B) of 50 participants each (normal saline [NS] + budesonide irrigation and NS irrigation alone, respectively). Pre- and post operative evaluation was done with a 22-item sinonasal outcomes test (SNOT-22), and Lund Kennedy endoscopic (LKE scores) in second and sixth week. Results: The condition of the patients significantly improved in both intervention arms related to SNOT-22 and LKE score at each postoperative visit (Group A: p Conclusion: Steroid nasal irrigation is a good option in postoperative EES patients. The difference of reduction of both SNOT 22 score and LKEscore was statistically significant (p Keywords: Chronic Rhinosinusitis, Budesonide, Saline irrigation

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Abstract

Introduction: Psoriasis is one of the skin disorder, mainly characterized by scaly papules and plaques. The etiology of psoriasis is multifactorial and still not properly understood. In our study, we tried to elucidate the relation between psoriasis and trace elemens namely Zinc, Copper and Selenium. Materials and Methods: This study enrolled 50 psoriasis patients with 37 males and 13 females, with 10- 80 years age. The patients were randomly selected from the outpatient clinic of Dermatology, Venereology and Leprosy Department, Narayana medical college and hospital. The age, sex matched 50 healthy volunteers included as controls in this study. Levels of serum Copper (Cu), Zinc(Zn), and Selenium(Se) analysed using Atomic absorption Spectrophotometery. Results: In our study, the mean Serum Zinc, Selenium and Copper levels were 61.968015.96824, 64.206017.44780 and 56.41208.51976 respectively, lower than the controls which was stastically significant (P Conclusion: In psoriasis, serum Cu, Zn and Se levels were observed to be low, needs to manage therapeutically by oral supplementation. More studies are required to carryout to standardize the diagnostic levels of Cu, Zn and Se and their role in psoriasis pathogenseis. Keywords: Psoriasis, Zinc, Copper, Selenium P Value 0667 0266.

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