Biji K Aravind

Abstract

Primary Myelofibrosis associated Nephropathy is a recently described entity. Primary Myelofibrosis (PMF) is a Myeloproliferative Neoplasm (MPN) where the marrow space shows fibrosis with megakaryocyte dysplasia. We present a case of a 32 year old patient who was detected to have proteinuria, renal dysfunction and anemia ,on a routine health check up. Primary Myelofibrosis was confirmed by positive Jak 2 expression. Kidney biopsy showed focal segmental glomerulosclerosis along with thickened glomerular basement membrane. The histomorphological features of renal and bonemarrow biopsies are analysed and a detailed review of the literature is done.   Keywords: Myeloproliferative neoplasm, Focal segmental glomeruloscerosis, Primary myelofibrosis

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Abstract

Intravascular Large B Cell Lymphoma (IVLBCL) is a unique subset of Diffuse Large B cell lymphoma. No randomised trials have been done on IVBCL till date as this a very rare type of Non Hodgkin Lymphoma. The clinical presentations are varied. The awareness about the disease and a high index of suspicion are required to diagnose a case of IVBCL. We report a case of 71 year old lady who was extensively investigated for fever of unknown origin, and finally one vessel in the bone marrow biopsy showed Intravascular Large B Cells. Keywords: Vascular, Lymphoma, B cell.

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