Shatavisa Mukherjee

Abstract

Drug induced lupus is an autoimmune condition secondary to drug exposure which leads to development of systemic lupus erythematosus (SLE). However, labelling the culprit drug needs a prudent insight into the pharmacological plausibility of each of the offending drugs in suspicion. Here we present a report where allergen immunotherapy was suspected to cause SLE and a deeper clinico-pharmacological evaluation cleared the air.   Keywords: Allergen Immunotherapy, Systemic Lupus Erythematosus, Drug induced lupus, Clinico pharmacological evaluation

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Abstract

Levothyroxine sodium (LT4) is a thyroid hormone prescribed as supplemental therapy in congenital and acquired hypothyroidism. This pathology is common in general population with an incidence of 4.1/1000 per year in women and 0.6/1000 per year in men. Though widely used, few cases of levothyroxine allergy are reported. Here we report a case of 44 year old male, who following two months of treatment initiation with L thyroxine 75 mcg, he manifested with hypersensitivity reactions progressing in form of maculopapular rash. Keywords: Levothyroxine Sodium, Maculopapular Rash, Cutaneous Adverse Drug Reaction, Drug Sensitivity Testing.

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Abstract

Introduction: The classification of lymphoid neoplasm has witnessed significant revisions over the years with the recent one simplifying the diagnosis and management of lesions at the very initial stages of lymphomagenesis. Different subtypes of lymphoid neoplasm vary in the different geographical locations. The present study aimed to probe the distribution of lymphoid neoplasm in Eastern India. Materials and Methods: A total of 79 cases of lymphadenopathy were included over a period of two years and were subjected to categorization according to WHO classification, using light microscopy and immunohistochemistry studies. Results: Of the 79 cases of lymphadenopathy studied, 35 cases were NHL, 21 cases were HL and rest other types. The ratio of NHL to HL as per our study was 1.66:1. Among NHL cases B-cell lymphomas were the predominant type accounting for 77.78% of all NHL cases, while T-cell lymphomas constitute 17.78% cases. Among HL, mixed cellularity variant was the commonest type (52.38%). followed by nodular sclerosis (33.33%) and lymphocyte predominance (9.52%). Conclusion: While DLBCL was the most common prevalent B cell NHL subtype followed by follicular lymphoma, Burkitt's lymphoma and High Grade B Cell lymphoma, ALCL was the most common T-cell lymphoma subtype followed by peripheral T cell lymphoma and Mycosis fungoides. Mixed cellularity was found the most common subtype of HL followed by the nodular sclerosis. Keywords: Hodgkin’s lymphoma, Lymphoid neoplasm, Non-Hodgkin’s lymphoma.

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