Agya Shrestha

Abstract

Small cell carcinoma of esophagus is tumor belonging to the family of extra-pulmonary small cell carcinoma. It is a highly aggressive tumor and early diagnosis and treatment is necessary for better prognosis of the tumor. We present a case of 45 year old male diagnosed with primary small cell carcinoma of esophagus and a review of literature of this rare tumor.   Keywords: Small cell, Oesophagus, Neuroendocrine

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Abstract

Glassy cell carcinoma of the cervix is a rare subtype of adenosquamous carcinoma associated with aggressive course and poor prognosis. It is considered to originate from the subcylindrical reserve cells of the cervix and has been associated with human papillomavirus. Histologically glassy cell carcinoma is composed of nestes of large cells with ground glass cytoplasm and large vesicular nuclei with prominent nucleoli. Nuclear pleomorphism and tumor giant cells are frequently seen. Mitotic activity is brisk. Infiltration by eosinophils and plasma cells with admixture of lymphocytes is a characteristic feature. Focal squamous and glandular differentiation may be seen. The immunohistochemistry markers are positive for squamous cell carcinoma (p63, CK34) and adenocarcinoma(MUC1, MUC2, CEA).Here we present a case of 49 year old female diagnosed as glassy cell carcinoma histologically and immunohistochemically. Keywords: Cervical cancer, Glassy cell carcinoma.

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