Nisarga Rani R

Abstract

Solitary intraductal papilloma of the breast is a common benign mammary proliferative disease and is the most common neoplasm associated with nipple discharge in women. Women with solitary papillomas have 1.5-2.0 times increased risk of developing invasive carcinoma. The papillary lesions of the breast include a broad spectrum of disorders from benign papilloma, atypical papilloma to papillary carcinoma. Benign papilloma on core needle biopsy has been found to have concurrent malignancy in about 3–5% of cases at excision. Solid papillomas commonly pose a diagnostic dilemma due to similarities with other ominous papillary lesions. The presence of ADH within a papilloma and/or in the surrounding breast is associated with an increased risk of recurrence or invasive carcinoma. The present study undertakes to fully describe the morphological changes occurring within the epithelial component of central papillomas and to search for factors of prognostic significance concerning recurrence, progression and differentiation of atypical ductal hyperplasia.   Keywords: Ductal papilloma, ADH, Proliferative breast disease

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Abstract

Primary testicular non-Hodgkin lymphoma (NHL) is an uncommon extra nodal lymphoma presentation, constituting 1-2% of all lymphomas. Majority are of B-Cell type, with very few cases being primary T-Cell phenotype. A 28 years male presented with painless, unilateral testicular swelling with elevated serum LDH levels, beta HCG and AFP serum levels were within normal limits. Gross evaluation of high inguinal orchidectomy specimen showed an enlarged homogenous, grey white lobulated mass with adjacent entrapped testicular parenchyma. Microscopy showed diffuse sheets of medium sized, monomorphic atypical lymphoid cells with sparing of adjacent seminiferous tubules. A panel of Immunohistochemistry markers done were suggestive of T-Cell Non-Hodgkin Lymphoma. Testicular T cell NHL are extremely rare amongst the testicular lymphomas, constituting for 5% of all testicular tumours. This case is being presented for its rarity in literature, especially in young age group and the unusual histomorphology.   Keywords: Non Hodgkin lymphoma, Peripheral T cell lymphoma, Testicular lymphoma

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Abstract

Cryptococcus neoformans is the most common life threatening fungal pathogen that infects patients with Acquired Immuno Deficiency Syndrome (AIDS). We present a case of 14 year old female came with complaints of bilateral non tender lymphadenopathy and mass per abdomen. On FNAC from lymphnode and spleen showed varying sized of cryptococcal organism which was further confirmed with Indian ink preparation. Following Human Immunodeficiency Virus test showed positivity. In immunocompromised individuals Cryptococcosis is the prevailing cause of death among opportunistic fungal disease. Greater number of studies showed the cryptococcosis in lung, meninges and skin whereas lymph node and spleen involvement is considered to be rare. We report a case of systemic cryptococcosis presenting as cervical lymphadenopathy and splenomegaly, diagnosed on fine needle aspiration cytology. Keywords: FNAC, Spleen, Lymph node, Cryptococcosis, Immunocompromised.

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