K.L. Senthilkumar

Abstract

Herbal toothpaste with natural ingredients is more acceptable in public opinion than chemical-based synthetic formulations in the current oral dental care scenario due to their safety and efficacy in reducing dental caries and preventing other dental disorders to which this generation is prone. In this composition, we use aloe Vera gel, clove oil, Neem powder, pomegranate peel powder, all of which have never been used before in any research. These extracts have anti-ulcer, anti-caries, anti-bacterial, and wound-healing properties, as well as certain unique properties including anti-cancer and anti-fungal. Herbal toothpastes were evaluated to determine important physical characteristics such as pH, stability, extrudability, spreadability, foamability, and homogeneity in order to develop a more effective and stable product. The purpose of this project is to make and test herbal toothpaste. This research proves that our herbal-based toothpaste formulation with natural ingredients is as excellent as it gets in terms of performance. Keywords: Herbal toothpaste, Anti­inflammatory activity, Dental care

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Abstract

The current research aims to formulate and evaluated medicated transdermal patches containing an anti-diabetic drug. A good penetration enhancer would improve drug delivery from various polymer-based transdermal patches. Transdermal patches of the matrix type are made. Using various PVP K30, MC ratios and solvent evaporation techniques. All prepared formulations were tested for weight variation, thickness, drug content, moisture content, moisture uptake, flatness, and in vitro drug release. Bath F3 was optimised formula from all formulation baths shows linear zero order release for 24 hours, with a cumulative percentage of drug diffusion of 87.35% from 4cm2 patches. It has been determined that polymer concentration. When the concentration of PVP K30 increases in the primary layer, the in – vitro diffusion rate increases, and when the concentration of PVP K30 decreases, the drug diffusion decreases. It allows for more controlled drug release from the patch. Keywords: Glimepiride, matrix type transdermal patch, PVP K30, Methyl cellulose, in­vitro study, and etc

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