Introduction: To report three cases with neurotrophic keratitis secondary to cerebrovascular accident and to highlight the importance of eliciting the history of previous stroke and their details in order to identify the cause of neurotrophic keratitis.
Materials and Methods: We present three cases of neurotrophic keratitis which presented many years later after a cerebro-vascular accident. The cases were misdiagnosed and treated as infectious keratitis earlier and the healing of epithelial defect posed a challenge. All the cases required surgical intervention to stabilize the eye and save the globe.
Results: The three cases of neurotrophic keratitis which were not responding to standard care of treatment and presented with persistent epithelial defect, which on enquiry revealed all patients had a previous history of stroke.
Conclusion: Cases of cerebrovascular accidents especially those who have medullary infarction require life long follow-up as corneal affection may develop many years later. These cases require a correct elucidation of history to arrive at the right diagnosis in order to initiate the appropriate treatment and ensure reduced morbidity.

Keywords: Neurotrophic keratitis, Persistent epithelial defect, Stroke.