Enhancing Precision of the Single-antigen Bead (SAB) Assay: Considerations and Challenges

Authors : Vikash Chandra Mishra, Vimarsh Raina

DOI : 10.14218/jctp.2023.00045

Volume : 4

Issue : 1

Year : 2024

Page No : 12-17

Our capacity to recognize and manage allosensitized transplant recipients and optimize organ allocation has been greatly improved by the development of single-antigen bead tests for detecting human leukocyte antigen antibodies. The main drawbacks of this technology have been thoroughly discussed in the literature, covering problems like artifacts that result in nonspecific background, variability, lack of uniformity, and difficulties in data interpretation. Consequently, it is not always easy to understand single-antigen bead data. This review will discuss the interpretation of donor-specific antibody data while considering the associated technical limitations. To ensure the correct clinical application of this test and to enhance the quality of antibody data used to support published clinical research in the era of epitope-based computational matching algorithms, a detailed understanding of the single-antigen bead assay is necessary.


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