Denosumab role in sacral aneurysmal bone cyst: A rare case report

Aneurysmal bone cyst (ABC) is a benign skeletal tumor which is eccentric, expansile and osteolytic lesion. It contains blood-filled spaces separated by fibrous septa. Aneurysmal bone cyst occurs most commonly in long bones and rarely in the sacrum. Because of its proximity to sacral nerve roots standard surgical resection or curettage and bone grafting is not optimal. Recent therapeutic strategy is to treat it with denosumab injections subcutaneously. We report a case of aneurysmal bone cyst involved in entire right half of sacrum in a 13 year old girl and we treated with denosumab injections (60mg/ml) subcutaneously in every month at regular interval for a period of 12 months and followed for a period of 1year, there was symptomatic and radiological improvement present.

Keywords: Aneurysmal bone cyst (ABC), Bone tumor, Sacrum, Denosumab.