Authors : D N Prakash, Sujata Sajjan, K Satish, Raghavendra R, Mohammed Abdul Kayoom
DOI : 10.18231/j.ijceo.2019.110
Volume : 5
Issue : 4
Year : 2019
Page No : 461-465
Objective: To study the therapeutic effects of 2% rebamipide ophthalmic suspension in dry eye disease.
Materials and Methods: It was Prospective study of 80 patients diagnosed with dry eye syndrome from
Jun 2016 to April 2017. After complete ophthalmic examination all were treated with 2% rebamipide
suspension. Dry eye-related Symptom Score, anterior segment examination with slit lamp, Tear Film
Break-Up Time, Fluorescein Ocular Surface Staining Score(FOS) & Schirmer test were used to collect
data from patients at baseline & at 2, 4, 8 & 12 week visits.
Results: Mean dry eye-related symptom score showed a significant improvement from baseline at 2, 4,
8 & 12 weeks (9.80, 7.20, 7.40 & 7.83 points). Median FOS also showed significant improvement from
baseline (3.0 points) at 2, 4, 8 & 12 weeks (2.0, 2.0, 1.0 & 1.0 points respectively). TBUT & Schirmer test
values also improved but were not significant after treatment.
Conclusion: 2% rebamipide ophthalmic suspension is an effective in treating dry eye. It helps in improving
both ocular & tear film stability.
Keywords: Dry eye syndrome, Tear film, Rebamipide, Mucin Secretion.