In-vitro postantibiotic effect (PAE) of ciprofloxacin against different bacterial species

The PAEs of ciprofloxacin against Salmonella dublin, E. coli, Pasteurella multusida and Staphylococcus aureus were determined. Growth curves of the organisms were constructed with and without addition of antibiotics and the two curves were compared. The longest PAE when it was subjected to an antibiotic (1 mg/ml ciprofloxacin) was observed against Staphylococcus aureus (6 hours) and the shortest was against Pasteurella multocida (1–2 hours), whereas the PAE of 4 hours was found for Salmonella dublin. E. coli was found to be resistant to ciprofloxacin in all phases.

Keywords: Ciprofloxacin, PAE, Salmonella dublin, E coli, Pasteurella multusida, Staphylococcus aureus.