Authors : Jyoti Titus, Madhur Gupta, Nitin Parekh, Suresh Chari.
Volume : 3
Issue : 1
Year : 2005
Page No : 97-99
Background: The prevalence of sickle cell disease (SCD) in western Odisha is 9.1 % which is a quite high figure if one looks at the morbidity and mortality out of it. In sickle-cell disease, low-oxygen tension promotes RBC sickling and repeated episodes of sickling damages the cell membrane and makes it rigid. Free radical promotes increased and irreversible sickling of RBC membrane by damaging it. Several newly emerging biological markers have potentiality to be utilized in deciding the degree of oxidative stress and disease severity.