Saba Khan

Abstract

A simple, rapid, accurate, economical and precise UV/VIS method has been developed and validated. Choices of a common solvent were essential so various solvent ranges including methanol, ethanol, acetonitrile, and 0.1 N HCL, and various concentrations ranges of various buffers were analyzed. Hence 0.1 N HCL was selected as a solvent for the proposed method. Caffeine showed maximum absorbance at 273nm.Drug obey Beer Lambert’s law in the concentration range of 3-18 ?g/mL for Caffeine. The LOD and LOQ were found to be 0.5476 ?g/mL and 1.6594 ?g/mL for Caffeine. The method was quantitatively evaluated in terms of linearity, precision, precision, LOD, LOQ and recovery. The method is simple, convenient and suitable for the analysis of Caffeine in bulk drugs. Keywords: Caffeine, Precision, Accuracy, Method development

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Abstract

There is stenosis or narrowing of the internal carotid artery in Moyamoya disease, a relatively rare kind of neurological condition. This may result in illnesses like ischemia, haemorrhage, or even a potentially fatal stroke. It is still unclear what this disease's specific pathogenesis is understood. The Moyamoya disease has a total of six stages. Scientists have not yet developed a drug that can fully treat moyamoya disease because it is such a rare disorder. Surgery is the only approach that works here. But once more, this won't help with finishing the course of treatment. It will only aid in slowing the spread of the disease. Keywords: Moyamoya, Cerebrovascular disease, Neurological

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Abstract

Drug repurposing (DR), also known as drug repositioning, is a strategy aimed at identifying new therapeutic uses for existing drugs. It offers an effective approach to discovering or developing drug molecules with novel pharmacological or therapeutic indications. In recent years, pharmaceutical companies have increasingly embraced the drug repurposing strategy in their drug discovery and development programs, leading to the identification of new biological targets. This strategy is highly efficient, time-saving, cost-effective, and carries a lower risk of failure compared to traditional drug discovery methods. By maximizing the therapeutic value of existing drugs, drug repurposing increases the likelihood of success. It serves as a valuable alternative to the lengthy, expensive, and resource-intensive process of finding new molecular entities (NMEs) through traditional or de novo drug discovery approaches. Drug repurposing combines activity-based or experimental methods with in silico-based or computational approaches to rationally develop or identify new uses for drug molecules. It leverages the existing safety data of drugs tested in humans and redirects their application based on valid target molecules. This approach holds great promise, particularly in addressing rare, difficult-to-treat diseases, and neglected diseases. By utilizing the wealth of knowledge and resources available, drug repurposing presents an emerging strategy for optimizing the therapeutic potential of existing medicines. It offers a pathway to rapidly identify effective treatments and repurpose approved drugs for new indications, benefiting patients and healthcare systems alike. Keywords: Repurposing, Discovery, Repositioned, Clinical trial

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