Amrut Arvindrao Dambal

Abstract

Background: Thyroid hormones are a potent regulator of metabolism, playing a crucial role in regulating energy expenditure and in key physiological mechanisms. Their prominent and well-known role is an increase in basal energy expenditure obtained by acting on carbohydrate, protein and lipid-metabolism. Hypothyroidism is relatively common and is associated with an unfavorable effect on lipid metabolism. Few studies reveal subclinical hypothyroidism to be a risk factor for increased incidence of lipid abnormalities and resulting in cardiovascular abnormalities. Aim: Hence study was taken up to find the association of serum lipids with subclinical hypothyroidism. Methodology: This was a retrospective study conducted in the department of Biochemistry, Malla Reddy hospital. Biochemically identified 102 subjects of Subclinical hypothyroidism subjects between 15-50 years and evaluated for lipid profile were included in the study. In our study, the mean serum total cholesterol, triglycerides, HDL cholesterol and LDL cholesterol expressed in mg/dl were 189.9824.16, 166.48+17.4, 37.62+2.89 and 121.34+27.31mg/dl respectively. 41 subjects out of 102 had higher total cholesterol, triglycerides and LDL cholesterol with lesser HDL cholesterol from the acceptable limits. Conclusion: We conclude that impaired lipid parameters are associated with subclinical hypothyroidism. Hence a regular screening for lipid profile should be considered in subclinical hypothyroidism for early diagnosis, prevention and management of cardiovascular complications. Keywords: TSH, HDL cholesterol, LDL cholesterol, Sub clinical hypothyroidism.

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Abstract

Introduction: Diabetes mellitus characterized by high glycemic levels is routinely associated with many mineral abnormalities. The purpose of this study was to evaluate the levels of serum magnesium among subjects with diabetes mellitus and to compare and analyze the same in normal non diabetics. Materials and Methods: In this case control study conducted at Malla Reddy Hospital, 50 subjects known to be diabetics were considered as cases and 50 apparently normal non- diabetics were the controls. Serum magnesium was estimated, compared and analyzed. Results: Serum magnesium levels were 1.89 ± 0.32 among cases and 2.26 ± 0.27 among controls. Extreme statistical significance was observed between both the groups. Conclusion: Serum magnesium levels were found to be decreased in subjects with diabetes mellitus. We conclude that diabetes mellitus could influence magnesium homeostasis. Keywords: Diabetes mellitus, Magnesium, Fasting plasma glucose.

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Introduction: In recent years, the care of patients has become increasingly dependent on the results of lab investigations. Lab investigations have always been and will continue to be an integral part of clinical practice. Clinicians focus their attention on the broader issue of protocols as a form of information management in medicine. While studies are available in western literature, in India studies regarding the utilization of lab services among clinicians are scant. Hence this study was done to assess the utilization of lab investigations by clinicians and also to take their perspective of lab practices so that it would help as a feedback and aids in improvement of lab services. Materials and Methods: A questionnaire consisting of 15 questions was distributed to 30 clinicians and their response to different questions was converted to percentage scale. Results: Majority of clinicians (86.6%) used lab services often. 33.3% felt that lab services were overutilised and the reason given was to aid in early diagnosis and for medico legal purposes. 33.3% of them had heard the term quality control but did not know its importance and 10 % had not heard of quality control. 76.6% of clinicians felt there is a need to include quality control and basic lab practices in MBBS curriculum. Conclusion: Laboratory services are utilized very often by clinicians. Majority of them felt the lab services are properly utilized. There is a need to include quality control and basic lab practices in MBBS curriculum. Keywords: Laboratory services, Quality control, Clinicians, Early diagnosis and treatment.

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