Authors : Audi Bhagyalakshmi, Amrut Arvindrao Dambal, D Sridevi, Prabhavati Modi, Lakshmi Chaitanya
DOI : 10.18231/j.ijcbr.2020.056
Volume : 7
Issue : 2
Year : 2020
Page No : 260-263
Background: Thyroid hormones are a potent regulator of metabolism, playing a crucial role in regulating
energy expenditure and in key physiological mechanisms. Their prominent and well-known role is an
increase in basal energy expenditure obtained by acting on carbohydrate, protein and lipid-metabolism.
Hypothyroidism is relatively common and is associated with an unfavorable effect on lipid metabolism. Few
studies reveal subclinical hypothyroidism to be a risk factor for increased incidence of lipid abnormalities
and resulting in cardiovascular abnormalities.
Aim: Hence study was taken up to find the association of serum lipids with subclinical hypothyroidism.
Methodology: This was a retrospective study conducted in the department of Biochemistry, Malla Reddy
hospital. Biochemically identified 102 subjects of Subclinical hypothyroidism subjects between 15-50 years
and evaluated for lipid profile were included in the study. In our study, the mean serum total cholesterol,
triglycerides, HDL cholesterol and LDL cholesterol expressed in mg/dl were 189.9824.16, 166.48+17.4,
37.62+2.89 and 121.34+27.31mg/dl respectively. 41 subjects out of 102 had higher total cholesterol,
triglycerides and LDL cholesterol with lesser HDL cholesterol from the acceptable limits.
Conclusion: We conclude that impaired lipid parameters are associated with subclinical hypothyroidism.
Hence a regular screening for lipid profile should be considered in subclinical hypothyroidism for early
diagnosis, prevention and management of cardiovascular complications.
Keywords: TSH, HDL cholesterol, LDL cholesterol, Sub clinical hypothyroidism.