Arpit Jain

Abstract

Background: Malignant melanoma has been known capable of inducing metastasis in most of the human organs. It is the most common metastatic tumor of the gastrointestinal (GI) tract; most commonly involving the small and large bowels and rectum; however, the stomach is a rare site. Gastrointestinal (GI) metastases are seldom diagnosed before death. Case Presentation: Here we present a known and treated case of malignant melanoma of left foot, later on presenting with non-specific gastric symptoms .UGIE revealed a growth in the gastric antrum for which mucosal biopsy was performed. Histopathology revealed a poorly differentiated carcinoma and with the help of IHC obtained a conclusion of metastatic lesion of malignant melanoma. Conclusion: Malignant melanoma of extremities warrants a thorough endoscopic evaluation for gastrointestinal metastases as > 60% cases are found to have lesions in stomach at autopsy. Hence an early diagnosis of the metastatic lesions mandate for better survival of the patients. Keywords: Malignant melanoma, Stomach metastasis.

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Abstract

We present a rare case of disseminated intravascular coagulation (DIC) as the initial manifestation of metastatic carcinoma of the prostate. DIC is a life-threatening condition characterized by systemic activation of coagulation and widespread microvascular thrombosis, leading to organ dysfunction. Although DIC is commonly associated with hematological malignancies and sepsis, its occurrence as a paraneoplastic syndrome in solid tumors is extremely rare. Our case highlights the importance of considering DIC as a potential complication in patients with advanced prostate cancer, even in the absence of typical symptoms.   Keywords: Disseminated intravascular coagulation, DIC, metastatic carcinoma, Prostate cancer, Paraneoplastic syndrome

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