Santosh Kondekar

Abstract

Introduction: Amikacin is an aminoglycoside used in the treatment of a wide variety of infections. It has the broadest spectrum of action amongst the aminoglycosides. It is often associated with dire side effects like nephrotoxicity and ototoxicty. The recommended dose for Amikacin is 15 mg/kg per day as a single dose. An 8 month infant was exposed to 10 times the normal amikacin dose. No treatment was given. Later on, no side effects were observed either. Previously overdoses like that observed in the above case have occurred. Those cases were immediately treated as opposed to our case and no further sequelae were observed in any of those cases either. There seems to be enough reason to doubt the need for immediate treatment in the case of amikacin overdose, instead, careful observation seems to be more appropriate. Keywords: Amikacin, Overdose, Children, Nephrotoxicity, Ototoxicity.

View Article

Abstract

Eight year old male child, born of non- consanguinity presented with complaints of irritability and drowsiness with history of left sided weakness. He was stunted and had hypertension at presentation. Also he had dysmorphic features and skin manifestations with skeletal deformities and muscle wasting.  Motor examination revealed muscle wasting with increased tone and decreased power on both sides. In Hutchinson -Gilford -Progeria syndrome, large and small vessel occlusive disease due to atherosclerosis can occur. CVA and Stroke can also result due to cerebral infarction or carotid artery occlusion. In our case, patient had MRI brain suggestive of areas of acute infarct and also evidence of chronic infarct and MR angiography suggestive of vasculopathic changes. Patient was started antihypertensives and tab asprin and gradually his sensorium improved, BP got normalized and planned discharge and advised regular follow up and physiotherapy. Keywords: Progeria, Stroke, HGPS.

View Article