Amit Gajanan Nerkar

Webinar was organized on Recent Advances in Pharmaceutical, Chemical and Biological Sciences on 15 Oct 2022. There were at total 8 speakers including the Chief Guest for the Webinar. Dr. Rahul K. Dumbre, Principal of CAYMET Siddhant College of Pharmacy, Sudumbare, Pune, M.S., India was the Convener for the Webinar. Dr. Amit G. Nerkar, Professor and Research Head, Siddhant College of Pharmacy and Founder and Director, Ateos Foundation of Science Education and Research, Pune, M.S., India was the Co-convener for the Webinar. At total 100 participants attended 8 sessions. The function started with Inauguration and concluded with Vote of Thanks by the Co-convener. Keywords: Pharmaceutical, Biological and Chemical Sciences, Webinar, CAYMET, AFSER

Zingiber officinale is a plant found locally in India that has been widely used as a flavouring agent in savoury dishes such as curries and sweets such as cakes and cookies, alcoholic beverages as well as in alcoholic beverages. like in tea. Ginger is a well-known herb, commonly used in traditional medicine all over the world. Ginger has been used for thousands of years to treat colds, nausea, arthritis, migraines, and high blood pressure. The many pharmacological activities of ginger are antiemetic, antidiabetic, analgesic, anti-inflammatory, anticancer, antioxidant, anticoagulant, antibacterial, anti-inflammatory, estrogenic and cardiovascular activities. Chemical irritants and an unsaturated phenolic ketone liquid C17H24O3 are responsible for the spicy taste of ginger. The main components of ginger are aromatic essential oils, antioxidants and pungent resins. These aromatic or pungent compounds have been identified as C6H5C(O)CH3, known as a chemical irritant, liquid unsaturated phenolic ketones C17H24O3 and Vanillylacetone. Keywords: Ginger, Ethnopharmacology, Anticancer activity, Pharmacognosy, Zingiber Officinale

The cultivation of Kalmegh (), a plant with numerous therapeutic benefits, has increased its significance as a medicinal plant. Given the plant's beneficial properties, it can be strongly recommended as a secure, crucial medicinal herb for people. There are many different chemical components in this herb, but the primary ones are lactones, diterpenoids, diterpene glycosides, flavonoids, and flavonoid glycosides. It possesses a wide range of pharmacological effects, including antibacterial, hepatoprotective, antitumor, anticancer, hypoglycemic, immunomodulatory, and hypotensive actions. This study describes the past and status of research on Andrographis paniculate palnt’s therapeutic utilisation. It also emphasizes at compiling vast pharmacological applications to make the potential image of  as a multipurpose medicinal agent. This ethnopharmacological review deals with anticancer activity of Kalmegh or A.paniculata. Keywords: A paniculata, Ethnopharmacology, Pharmacognosy, Extract, Anticancer, Kalmegh

The strive of this assessment shows that Vinca rosea, many obviously grown vegetation round us which can be used for medicinal purposes. It has many known names like vinca Rosea, Madagascar periwinkle, vibrant eyes, Cape periwinkle, graveyard plant, old maid, crimson periwinkle, rose periwinkle myrtle. Ayurveda is the Indian conventional device of medication which focuses on the scientific capability of plant life. Catharanthus roseus is one plant recognized nicely in Ayurveda. It is known for its antitumour, anti-diabetic, anti-microbial, anti-oxidant and antimutagenic effects. It is an evergreen plant first originated from islands of Madagascar. The flowers can also range in color from red to pink and leaves are organized in opposite pairs. It produces nearly 130 alkaloids especially ajmalcine, vinceine, resperine, vincristine, vinblastine and raubasin. Vincristine and vinblastine are used for the treatment of various types of cancer such as Hodgkin’s disease, breast cancer, skin cancer and lymphoblastic leukemia. It has high medicinal values which need to be explored considerably. This ethnopharmacological review deals with anticancer activities and pharmacognostic study of Vinca plant. Keywords: Vicna, Catharanthus, Roseus spp, Anticancer, Pharmacognosy, Ethnopharmacology

Boswellic acid is an Ursane group compound belonging to triterpenoids. It is the major constituents of the gum derived from plant Roxb. It belongs to Family Burseraceae. It is also known as and commonly known as the Salai guggal, white guggal, Indian olibanum. is medium-sized tree widely distributed in the India and Africa. B. Serrata is highly medicinal as well as economically potential. Currently, it is has the potential use in various herbal and ayurvedic formulations for the treatment of various disorders which include inflammation and other types of disorders. Since ancient and centuries anti-cancer drugs discovered from herbal medicines have been used in clinical practice. The active constituent of such formulations being vincristine, vinblastine and the camptothecene derivatives, topotecan, irinotecan and etoposide. There is current need for herbal and ethnopharmacological therapeutics to develop the novel anti-cancer drugs which is safe with effective mechanism. The new discoveries of developing combined ingredients from effective traditional formula or single ingredient as per the traditional medicine theory should be focused. This new approach will promote the academic research and the industry development of traditional medicine. This ethnopharmacological review is mainly focused on anticancer activity of. Keywords: Boswellia, Anticancer, Ethnopharmacology, Boswellic acids, Phytochemistry

Medicinal chemistry has been the backbone of the pharmacy profession. Medicinal chemistry may be defined as chemistry of medicines. This allied branch with pharmacology is being taken as a cumbersome and troublesome subject. This review deals with the mostly incorrect practice and assumptions of Medicinal chemistry as a theoretical subject being taught at the college level for diploma, undergraduate, postgraduate, and doctoral studies.  

Cardiac arrest is the incapability of the heart to pump blood efficiently to essential organs of the frame consisting of lungs, brain, etc. ensuing in lack of cognizance and breathing. Cardiac arrest takes place whilst the coronary heart stops beating. Cardiac arrest is likewise referred to as cardiopulmonary arrest (CPA) or circulatory arrest. It is a main purpose of loss of life worldwide. Cardiac arrest isn't like coronary heart attack. Heart attack takes place whilst an artery wearing oxygen-rich blood to a selected vicinity of the coronary heart is blocked. This results in inadequate delivery of blood to that vicinity and might purpose everlasting harm if the blocked artery isn't reopened. Longer the affected person is going untreated extra may be the harm to coronary heart. Symptoms of coronary heart attack consist of soreness withinside the chest and different components of the higher frame, uneasiness, shortness of breath, +bloodless sweats, nausea and vomiting. In this review the pharmacotherapy of the cardiac arrest has been discussed. Keywords: Cardiac arrest, Pharmacotherapy, Vasodilators, Corticosteroids, etc

WHO (World Health Organization) termed the diagnosed coronavirus as COVID-19. The pandemic outbreak of COVID-19 was manifested by intense acute respiratory system (SARS) and in Middle East known as Middle East Respiratory Syndrome (MERS). An outbreak of pneumonia of unknown aetiology in Wuhan City, Hubei province in China emerged in December of 2019. The virus originated in bats and became transmitted to people through but unknown middleman animals in Wuhan, China. There was not any clinically authorised antiviral drug to be had for use in opposition to COVID-19. However, few extensive-spectrum antiviral pills had been evaluated in opposition to COVID-19 in scientific trials, led to scientific recovery. In the cutting-edge evaluate, we summarize and relatively examine the worldwide emergence and pathogenicity of COVID-19 contamination. Keywords: COVID­19, Corona virus, SARS, MERS, Pneumonia

Growth factors receptors and hormones play an important role several cell minor cell types.With advent of advancement in Breast cancer (BC) treatment and therapies ther of there has been major advancement in this area after this discovery. The combined sciences of cellular biology and therapeutic fields have made the breast cancer a seized cure area for discoveries of new therapies and its design including the heterogeneity. This article reviews the numerous prospective innovative therapies for targeting major cell subtypes of BC cells, as well as the present therapeutic regimens. In the personalised BC drug, speedy scientific advancement of poly inhibitors (ADP-ribose) polymerase, cyclin-dependent kinases four and six, phosphatidylinositol 3-kinase / protein kinase b / mammalian target rapamycin pathway, histone deacetylation, multi-concentrated in tyrosine kinases, as well as antibodies. The Triple negative breast cancer (TNBC) has been the most challenging area for design of therapies and for drug discovery. For TNBC, as such there is no approved treatment and it is most dangerous type of BC. The article also discusses the TNBC heterogeneity and TNBC molecular subtyping. It could also help find medications to treat this terrible disease. The cell proliferation and propagation inhibitors for treatment-resistant strains also puts the invention of targets for small molecules of BC in concern. Keywords: Breast cancer, Inhibitors of cyclin-dependent kinases 4 and 6, Hormone receptor, Human epidermal growth factor receptor 2, Poly (ADP-ribose) polymerase inhibitor

Pharmaceutical marketing is an integral part of pharmaceutical business or trade. There has been significant increase in pharmaceutical generic, branded, ethical and barded generic drugs being marketed in India and being manufactured on Third party contract basis. There are several companies which manufacture the pharmaceutical medicines on third party basis and rarely possess their own units or pharmaceutical manufacturing plants. In this context the good and evil in marketing practices has been reviewed in this editorial. Keywords: Editorial, Pharmaceutical Marketing Practices, Ethical, Generics

In the beginning of 2020, India was hit by corona wave and Pharmacy of the Word, our nation, India had lend a helping hand for entire world. In this context and with the actual industrial practice and the suggested measures are discussed for the academia and Pharmacy Council of India to develop better pharmacy graduates cope up the need of the existing practices in Industrial Pharmacy world. Keywords: Industrial Pharmacy, Pharmacy Council of India, Academia, Suggestions

Melanomas especially metastatic melanoma chemotherapeutic treatment has been discussed in the review article. The recent advancement in the chemotherapy being Immunotherapy targeted therapy, combination therapy, targeted therapy, combination therapies and biochemotherpies all of which have been discussed in this review article. Keywords: Metastatic melanomas, Immune therapies, Combination therapies, Bio-chemotherapies, Targeted therapies.

The advance head and neck cancers are most difficult for treatment. The newer approaches for the treatment being systemic chemotherapy combined with radiotherapy. Chemotherapy offers several advantages in metastatic head and neck cancers. The main choice for the systemic chemotherapy being platinum containing compounds (drugs), Taxanes, in recent years have shown to be promising and being included in the neo-adjuvant and concomitant therapy regimes. Further, targeted agents such as epidermal growth factor receptor inhibitors (EGFRIs) have proven to be beneficial in concomitant and metastatic therapies. Keywords: SCCHN, Cisplatin, EGFR

The natural products have played a dominant role in the treatment of human ailments. The discovery of penicillin has changed the scenario of modern medicine. With the ancient use of quinine for malaria, willow bark for pain and several other natural products used as medicines in ancient system of medicine such as Ayurveda and traditional China, the discovery of the medicines for the allopathic use from natural source has gained substantial attention. The ancient system of Ayurveda describes the used of many plants extracts being used for the treatment of cancer. Prevailing epidemiological factors have also described the use of the msediterranean diet and inclusion of fruits and vegetables to score low as risk factor for the cancers. Further the several discoveries have led to the transformation of the active constituents of the natural products from the dietary sources for the chemoprevention. Substantial trials in the development of the drugs from the marine and microbial origin have been fruitful and positive to develop safe and efficacious drugs. However, the success being very low due to unavailability of natural products in large gram amounts required for the clinical trials. The total synthesis of m any natural products from marine origin has also emerged to solve this issue and led to successful development of 4 marine drugs as anti-cancer agents. This overview reviews the anticancer drugs from the natural origin as the chemo preventive and chemotherapeutic agents. Wherever possible the details of the clinical trials have been discussed along with uses and mechanism of action. Keywords: Antitumor drugs, Chemoprevention, Drug discovery, Natural product drug sources

Osteosarcoma (OS) is a type of cancer with onset in late childhood and peak at early adolescence. OS is a typically is chemo sensitive cancer. The treatment modalities include neo-adjuvant and adjuvant therapies with definitive surgery. Permutations and combinations of chemotherapeutics agents have been used. However, in many clinical trial high dose methotrexate has been used as main drug with cisplatin and doxorubicin (MAP). In recent years, case studies have cited addition of fourth drug to the three drug regimen gives a detail of drug regimen being used over past years and discusses the successful treatment. Keywords: Methotrexate, Ifosfamide, Cisplatin

Niosome are non-ionic surfactant vesicles. These are obtained by hydrating combination of cholesterol and non-ionic surfactants. It is used as carrier for amphiphilic and lipophilic medicine. Niosomes are identity assemble vesicles collected largely of artificial surfactants and cholesterol. Drug delivery potential of niosomes can be enhanced in use of novel drug delivery concepts similar to proniosomes, discomes and aspasomes. By reducing the clearance the rate of noisomes they provide better help in analytic imaging and as a vaccine adjuvant. As well as they supply better support in analytic imaging and as a vaccine adjuvant. This short communication reviews the niosomes. Keywords: Noisome, Cholesterol, Hydrophilic and Lipophilic medicine, Surfactant, Adjuvant, Research, Biodegradable

Gene therapy is used to correct defective genes in order to cure a disease or help your body better fight disease. Gene therapy is the introduction, removal or change in genetic material specifically DNA or RNA into the cells of a patient to treat a specific disease. Disease is caused to mutation. Genes influence all from the color of our hair to immune system, but genes are not built correctly. Targets of the gene therapy causing diseases. Gene therapy uses section of DNACurrently gene therapy is being tested only for disease that have no. other cures. Interest area of this review covers introduction, history, DNA transfer, Types of gene therapy, working of therapy, techniques, Delivery system, strategies, technique challenges, risks, gene introduction site and clinical applications of gene therapy. Keywords: DNA, Therapy

Neem (Azadirachta indica) belonging to Maliaceae family is very important medicinal plant. Neem is used different medicinal system; Ayurveda, Unani, Homeopathic medicines against various diseases. Each part of neem tree which has some medical property which act on various diseases. Keywords: Azadirachtaindica, Medicinal uses, Preparations Introduction:

Water born enteric viruses pose thread to both human and animal life causing a wide range of illness. Ground water is the commonest transmission route for these viruses. About 50% of ground water related outbreaks are attributed to viruses. Viral infections have a long history of association with drinking water supplies. Evidence of water-borne transmission is predominantly based on epidemiological data. Water-borne disease transmission has only in exceptional cases been confirmed by direct detection of viruses in drinking water supplies. Water, a frequent vehicle, may permit their survival, but many environmental factors will have an adverse effect on the viral pollution. Risk evaluation requires identification of these factor and assessment of inactivation rate of infection viruses. Keywords: Viruses, Water, Water-borne outbreaks, Enteric

Morinda citrifolia is a fruit-bearing tree in the coffee belonging to the family, Rubiaceae. Its native range extends through Southeast Asia and Australasia, and become spread through the Pacific by Polynesian sailors. The species is now cultivated all through the tropics and widely naturalized. Among a few one hundred names for the fruit throughout special areas different areas are the more common English names are morinda, Indian mulberry, noni, beach mulberry, and cheese fruit. Indian Mulberry has various pharmacological properties such as anticancer, antidiabetic, antistress, antioxidant, anxiolytic, immunomodulatory, cholesterol lowering, lipid lowering, nephroprotective, hepatoprotective and anti-cancer plant which help in maintaining body strength and curing cancer causing germ cells by eradicating them. The syrup is most used and a popular dosage form. It has many applications and many of the treatments are based on the usage of syrup for patients’ compliance at every age. The herbal syrup was formulated using extract of Indian Mulberry or Noni as the main ingredient along with invert sugar base. Indian Mulberry or Noni has been used in the treatment of cancer because of many stresses condition and other oxidative reaction in body the free radical is generated by using these, syrup the condition is overcome. Formulation at laboratory scale was done of herbal syrup and evaluated for number of parameters such as PH, viscosity, density, stability testing during evaluation formulation found to be stable and ready formulas viz. F1, F2, F3 and F4 were prepared with variation in the amount of ingredients such as alcohol, sugar and a final amount of syrup. All formulations were prepared according to parameters such as density, specific gravity, pH, organoleptic properties. Results show that Herbal Syrup Formula 4 (F4) is more stable than other forms. Keywords: Herbal Syrup, Indian Mulberry, Anticancer activity, Evaluation

The cultivation of Kalmegh (Andrographis paniculata), a plant with many medicinal benefits, has increased its importance as a medicinal plant. Considering the beneficial properties of the plant, it can be appreciated as a safe and important herb for humans. There are many different chemical constituents in this herb, but the main ones are lactones, diterpenoids, diterpene glycosides, flavonoids and flavonoid glycosides. It has a wide range of pharmacological effects, including antibacterial, hepatoprotective, antitumor, antitumor, hypoglycemic, immunomodulatory, and antihypertensive. Lab scale formulation is made with herbal syrup and evaluated for several parameters like pH, viscosity, density, stability test while evaluating the formula. is a stable and ready-to-know recipe. F1, F2, F3 and F4 are made with different amounts of ingredients such as alcohol, sugar and a final amount of syrup. Results show that Herbal Syrup Formula 4 (F4) is more stable than other forms. Keywords: Herbal Syrup, Kalmegh, A paniculata, Evaluation

Semecarpus anacardium Linn. (Family: Anacardiaceae), commonly known as 'Bhallataka' or 'Bhilwa', has been used in various traditional systems of medicine to treat various ailments since ancient times. Its nuts contain many bioactive compounds such as biflavonoids, phenolics, bhilawanols, minerals, vitamins and amino acids, which exhibit various healing properties. Fruit and seed extracts exhibit various activities such as anti-atherogenic, anti-inflammatory, antioxidant, antibacterial, anti-reproductive, CNS stimulant, hypoglycemic, antitumor, and growth stimulant. hair. Lab scale formulation is made with herbal syrup and evaluated for several parameters like pH, viscosity, density, stability test while evaluating the formula. Is a stable and ready-to-know recipe. F1, F2, F3 and F4 are made with different amounts of ingredients such as alcohol, sugar and a final amount of syrup. Results show that Herbal Syrup Formula 4 (F4) is more stable than other forms. Keywords: Herbal Syrup, Bhilawa, Evaluation, S Anacardium, Syrup

Zingiber officinale is a plant found locally in India that is widely used as a flavoring agent in savory dishes such as curries and sweets such as cakes and biscuits, alcoholic beverages as well. like in tea. Ginger is a well-known herb, commonly used in traditional medicine all over the world. Ginger has been used for thousands of years to treat colds, nausea, arthritis, migraines, and high blood pressure. The many pharmacological activities of ginger are antiemetic, antidiabetic, analgesic, anti-arthritis, anticancer, antioxidant, anti-ulcer, antibacterial, anti-inflammatory, estrogenic and cardiovascular. A chemical stimulant and an unsaturated liquid phenolic ketone C17H24O3 are responsible for the pungent taste of ginger. The main components of ginger are aromatic essential oils, antioxidants and pungent oleoresin. These aromatic or spicy compounds have been identified as C6H5C(O)CH3, known as a chemical stimulant, phenolic ketone unsaturated liquid C17H24O3 and Vanillylacetone. Lab-scale formulation is made with herbal syrup and evaluated for several parameters such as pH, viscosity, density, stability testing during formulation evaluation. is a stable and ready-to-know formula. F1, F2, F3 and F4 have been prepared with different amounts of ingredients such as alcohol, sugar and a final amount of syrup. Results show that Herbal Syrup Formula 4 (F4) is more stable than other forms. Keywords: Herbal Syrup, Ginger, Zingiber Officinale, Evaluation, Formulation

In the Indian subcontinent, turmeric (Curcuma longa Linn) is widely grown and consumed as a spice. Traditional medicine has used turmeric to treat a variety of ailments, such as diabetes, liver disease, and cough. Many studies have been conducted over the past decades to determine the pharmacological effects of turmeric and its derivatives. The main chemical component of turmeric, curcumin, has been shown to have pharmacological properties, including anti-inflammatory, antioxidant, anti-mutagenic, antidiabetic, and antibacterial properties. , protect liver, expectorant and anti-cancer. Turmeric, also known as Curcuma longa L. (root and rhizome), is a plant of high medicinal and commercial value, mainly used as a spice and functional food around the world. Three curcuminoids - curcumin (diferuloylmethane, the main ingredient that gives turmeric its yellow color), demethoxycurcumin, and bisdemethoxycurcumin - are the main active ingredients in turmeric. Volatile oils (zingiberene, atlantone, tomerol, etc.) also have pharmacological effects. In addition, turmeric contains proteins, resins and carbohydrates. Turmeric is a powerful antioxidant and has significant anti-inflammatory properties. Turmeric's anti-inflammatory properties may be directly related to its anti-cancer properties. Lab-scale formulation was made with herbal syrup and evaluated for several parameters such as pH, viscosity, density, stability testing during formulation evaluation. is a stable and ready-to-know formula. F1, F2, F3 and F4 have been prepared with different amounts of ingredients such as alcohol, sugar and a final amount of syrup. Results show that Herbal Syrup Formula 4 (F4) is more stable than other forms. Keywords: Herbal Syrup,Turmeric, Curcuma Longa, Evaluation, Formulation

The use of herbal medicines alone or in combination is increasing in human health care. Medicinal plants may be an important source of previously unknown chemicals with potential therapeutic effects. Terminalia arjuna bark is commonly known as Arjuna or Arjun bark and is abundant throughout India. This plant contains 15% tannins, triterpenoid saponins, flavonoids, calcium, aluminium and magnesium salts as well as colorants and sugars which are other components of Arjun. The Terminalia arjuna plant has many therapeutic properties and is capable of treating many ailments, especially heart and circulatory system diseases. This plant is an excellent means of lipid-lowering, anticoagulant, antihypertensive, antiviral, antithrombotic, antifungal and antibacterial. The plant's therapeutic properties related to heart health are due to the triterpenoids enclosed by the arjuna plant. Likewise, the flavonoids and tannins naturally present in this herb have anti-cancer properties. This review provides a key overview of the therapeutic profile, traditional uses, phytochemistry and across different plant parts. Keywords: T Arjuna, Complimentary Medicine, Alternative Medicine, Ethnopharmacology, Anticancer

These reviews suggest that in the Indian subcontinent, turmeric (Curcuma longa Linn) is widely grown and consumed as a spice. Traditional medicine has used turmeric to treat a variety of ailments, such as diabetes, liver disease, and cough. Many studies have been conducted over the past decades to determine the pharmacological effects of turmeric and its derivatives. The main chemical component of turmeric, curcumin, has been shown to have pharmacological properties including anti-inflammatory, antioxidant, anti-mutagenic, antidiabetic, and antibacterial properties., protect liver, expectorant and anti-cancer. Turmeric, also known as Curcuma longa L. (root and rhizome), is a plant of high medicinal and commercial value, mainly used as a spice and food supplement around the world. The three curcuminoids - curcumin (diferuloylmethane, the main ingredient that gives turmeric its yellow color), demethoxycurcumin, and bisdemethoxycurcumin - are the main active ingredients of turmeric. Volatile oils (zingiberene, atlantone, tomerol, etc.) also have pharmacological effects. In addition, turmeric contains proteins, resins and carbohydrates. Turmeric is a powerful antioxidant and has significant anti-inflammatory properties. Turmeric's anti-inflammatory properties may be directly related to its anti-cancer properties. In this review, the anticancer properties of Turmeric have been reviewed. Keywords: Turmeric, Curcumin Linn, Anticancer, Ethnopharmacology, Pharmacology, Pharmacognosy

The most difficult subject for students of Pharmacy or Pharmaceutical Sciences undergraduates and postgraduates is Pharmaceutical Organic Chemistry. The professor teaching this subject should be well versed with basic concepts of the Organic Chemistry belonging to the specialization of Chemical Sciences. The Pharmaceutical Organic Chemistry specialization has vast scope, and the teaching professor needs to clear the basics concepts of the subject. In this connection the actual teaching aesthetics of Pharmaceutical Organic Chemistry (POC) has been described. The review is an attempt to summarize the importance of the POC and make aware the teachers of Indian and Foreign Universities for the new direction and aesthetics of the teaching of the same. Keywords: Pharmaceutical Organic Chemistry, Pharmacy, Pharmaceutical Chemistry, Pharmaceutical Sciences

Pharmacology is one of the most interesting common subjects of studies to pharmaceutical sciences or pharmacy, medicine and some life sciences and biomedical sciences undergraduates, postgraduates, doctorates, and Post doctorates. The art of teaching Pharmacology and Clinical Pharmacology lies in the in-depth knowledge of the tutor or the in-charge professor. This editorial deals with actual teaching aesthetics of teaching Pharmacology and Clinical Pharmacology right away from the basics and in advance science. The article will be useful for all the tutors and professors in pharmaceutical sciences or pharmacy, medicine, and biomedical sciences to implement effective teaching and learning in pharmacology and clinical pharmacology.   Keywords: Pharmacology, Clinical pharmacology, Actual, Teaching aesthetics, Basics

Natural products with immunomodulatory effects are widely used in the treatment of many diseases, including autoimmune diseases, as well as cancer and inflammatory diseases. They have attracted great interest as therapeutic agents in recent decades because they offer inexpensive and less toxic products than synthetic chemotherapy agents. Immunomodulators are substances that have the ability to improve or suppress the host's defense response, which can be used for prevention and in combination with other treatments. The anticancer effects of these immunomodulators result from their anti-inflammatory, antioxidant and apoptosis-inducing, anti-angiogenic and anti-metastatic effects. In addition to preventing tumor growth and proliferation, these natural immunomodulators, such as curcumin and Vinca, can also be used as a preventive treatment against cancer. In contrast, immunostimulants can induce and activate humoral and cell-mediated immune responses against the tumor, which facilitates the recognition and destruction of a pre-existing tumor.   Keywords: Ehtnopharmacology, Vinca, Turmeric, Review, Periwinkle, Curcumin

Calotropis gigantea also in Indian system known as Madar plant, the weed is also known as giant weed. Trees of the family Apocynaceae include latex-bearing trees and are mainly endemic to Indian Asian subcontinent countries. In recent decades C. Gigantea is extensively studied and found to possess many bioactive compounds. This plant has been reported for several pharmacological properties such as analgesic activity, antibacterial activity, antioxidant activity, antipyretic activity, insecticidal activity, cytotoxic activity, and cytotoxic activity. Hepatoprotective, pregnancy-preventing, cleansing properties, procoagulant and curative activity. The study focused on the formulation and evaluation of herbal medicinal syrups from C. gigantea. Four herbal syrups have been prepared with an optimized F4 formulation and can be developed on a commercial scale.   Keywords: Formulation, Evaluation, Syrup, Madar, Calotropis Gigantea

A cepa or onion is the most edible vegetable throughout the world. It also has diverse pharmacological properties. It is a fibrous perennial plant belonging to the Amaryllidaceae family. Onions contain vitamins such as folic acid and vitamin B6. It also contains minerals such as magnesium, calcium, potassium, and phosphorus. It shows diverse pharmacological properties such as anticancer, antidiabetic, antioxidant, anticoagulant, antihypertensive and antidepressant and neuroprotective effects. It is believed to be a carminative and shows beneficial effects on circulatory and respiratory systems as well as the immune system. Allium cepa finds its uses in cancer because of many stress conditions such as oxidative stress can be subsided by the Allium cepa extract and formulations. In this review, an attempt was made to formulate the medicated syrup of A. cepa. Four such formulations were made (F1, F2, F3, F4). The F4 formulation was optimized and was stable. The Formulation F4 can be adopted for preparation of A. cepa syrup on Industrial scale.   Keywords: Formulation, Evaluation, Herbal Syrup, Onion, Allium Cepa

In continuation of previous research, the anticancer screening of formulation of Herbal syrup of Turmeric extract was performed. The formulation of herbal syrup was performed as per reported literature method. The anticancer cancer screening was performed on two Human cancer cell lines. These cell lines were Human Lung Cancer cell line A549 and Human Breast Cancer Cell line MCF7. The formulation was found to be devoid of anticancer properties.   Keywords: In vitro Anticancer, Herbal, Syrup, Turmeric, Extract

In continuation of previous research, the anticancer screening of formulation of herbal syrup of Vinca extract was performed. The formulation of herbal syrup was performed as per reported literature method. The anticancer cancer screening was performed on two Human cancer cell lines. These cell lines were Human Lung Cancer cell line A549 and Human Breast Cancer Cell line MCF7. The formulation was found to be devoid of anticancer properties.   Keywords: In vitro, Anticancer, Herbal, syrup, Vinca, Extract