Authors: Ashok Agrawal, Anita Mehta
Now a day most of the patients on long term therapy of glucocorticoid become insensitive to corticosteroids and addition of vitamin D to such patients may enhance to response to corticosteroids. Therefore, we investigated anti-inflammatory activity of vitamin D in presence of glucocorticoids receptor antagonist; mifepristone, to assess whether, vitamin D acts as dependent or independently from glucocorticoids receptor. Wistar albino rats were sensitized with ovalbumin (OVA) and, upon OVA challenge, developed airway eosinophilia and neutrophilia. Administration of dextamethasone, vitamin D and combination of dextamethasone+vitamin D, and dextamethasone+vitamin D+mifepristone significantly (P Keywords: Asthma, Vitamin D, Mifepristone.
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