Vitamin D acts as independently from glucocorticoid receptor in animal model of asthma

Authors : Ashok Agrawal, Anita Mehta

DOI : 10.18231/j.ijpp.2021.012

Volume : 8

Issue : 1

Year : 2021

Page No : 74-77

Now a day most of the patients on long term therapy of glucocorticoid become insensitive to corticosteroids and addition of vitamin D to such patients may enhance to response to corticosteroids. Therefore, we investigated anti-inflammatory activity of vitamin D in presence of glucocorticoids receptor antagonist; mifepristone, to assess whether, vitamin D acts as dependent or independently from glucocorticoids receptor. Wistar albino rats were sensitized with ovalbumin (OVA) and, upon OVA challenge, developed
airway eosinophilia and neutrophilia. Administration of dextamethasone, vitamin D and combination of dextamethasone+vitamin D, and dextamethasone+vitamin D+mifepristone significantly (P<0>

Keywords: Asthma, Vitamin D, Mifepristone.

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