Jayshri Sadashiv Jankar

Abstract

Background: Serum ferritin, an acute phase reactant, is an indicator of the body's iron reserves. Increased body iron reserves and subclinical hemochromatosis have been linked to the development of hyperglycaemia, type 2 diabetes, metabolic syndrome, and potentially diabetic retinopathy, nephropathy, and vascular dysfunction, according to recent research. The objective of this study was to see if there was a link between Serum Ferritin and Type 2 diabetes and metabolic syndrome, as well as to see if there was a link between S. ferritin and HbA1c. Materials and Methods: The present study included 50 diagnosed cases of type 2 diabetes mellitus (males: 32, females: 18) and 50 healthy controls of same age (males: 28, females: 22). Serum ferritin levels, glycated hemoglobin were measured and compared. Results: When diabetic patients were compared to controls, serum ferritin was considerably greater, and serum ferritin had a positive correlation with the duration of diabetes and glycated hemoglobin. Conclusions: Positive correlation was found between serum ferritin levels and glycated hemoglobin and duration of disease.   Keywords: Ferritin, Type 2 diabetes mellitus, Glycated hemoglobin, HbA1c.

Open full article page

Abstract

Introduction: Nitric oxide (NO) is known as a mediator in a broad cluster of biological systems. NO is the endothelium-derived relaxing factor, which causes vasodilation by relaxing vascular smooth muscle. This role of NO plays an important role of diabetic nephropathy in Type 2 Diabetes Mellitus (DM) Aims: To assess serum nitric oxide levels among type 2 diabetes mellitus patients having normoalbuminuria and microalbuminuria. Setting and Design: This cross sectional study was carried out at Department of Biochemistry in a tertiary care rural hospital in Central India with 200 diagnosed patients of type 2 diabetes mellitus. Materials and Methods: 24 hr urine albumin was done in all the patients. Based on the concentration of albumin in urine, patients were categorised in two groups, group 1 had normoalbuminuria (i.e. Urine Albumin <20 mg/ 24 hr) and group 2 had microalbuminuria (i.e. Urine Albumin >20 to <300 mg/24 hr). Then, serum NO was assessed and compared in these groups. Results: Serum NO levels were significantly raised (p <0.05) in Group 2 as compared to Group 1. Conclusion: Our observations suggest that serum NO levels measurement has a good detection potential for early stages of diabetic nephropathy manifested in the form of microalbuminuria in Type 2 DM. Keywords: Diabetic Nephropathy, Microalbuminuria, Nitric Oxide, Normoalbuminuria.

Open full article page