Assessment of lipid per-oxidation and endothelial dysfunction in patients of coronary artery disease

Authors : Anita Sharma, Ashish Sharma

DOI : 10.18231/2394-6377.2019.0003

Volume : 6

Issue : 1

Year : 2019

Page No : 7-9

Aim: To find the difference in the levels of homocysteine and lipid-peroxidation in male and female patients of coronary artery disease.
Materials and Methods: 71 subjects were included in this study over a period of 12 months out of which 12 female patient of CAD, 29 male patient of CAD and 30 were normal healthy subjects as controls. Estimation of plasma malondialdehyde (MDA) was done by colorimetric technique on RA 50 semi-automated chemistry analyzer. The homocysteine level in the plasma was estimated using the Hcy enzymatic assay on SYNCHRON CX5, Automated Chemistry Analyzer of Beckman Coulter Ltd.
Results: We found significant increased levels of Hcy and MDA in male CAD patients than in female CAD patients.
Conclusion: In female CAD patients, decreased levels of Hcy and MDA areindication of low oxidative stress that may be due to female sex hormones.

Keywords: Coronary artery disease (CAD), Homocysteine (Hcy), Lipid-peroxidation, S-adenosylhomocysteine (SAH).

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